{"id":157305,"date":"2024-08-13T13:42:13","date_gmt":"2024-08-13T19:42:13","guid":{"rendered":"https:\/\/www.globaldownsyndrome.org\/?p=157305"},"modified":"2024-08-13T13:42:46","modified_gmt":"2024-08-13T19:42:46","slug":"studimi-klinik-i-institutit-crnic-tregon-se-frenuesi-jak-permireson-gjendjet-e-shumta-autoimune-ne-pacientet-me-sindromen-down","status":"publish","type":"post","link":"https:\/\/www.globaldownsyndrome.org\/sq\/crnic-institute-clinical-trial-shows-jak-inhibitor-improves-multiple-autoimmune-conditions-in-patients-with-down-syndrome\/","title":{"rendered":"Prova klinike e Institutit Crnic tregon se frenuesi JAK p\u00ebrmir\u00ebson gjendjet e shum\u00ebfishta autoimune n\u00eb pacient\u00ebt me sindrom\u00ebn Down"},"content":{"rendered":"

Denver, 13 gusht 2024 (GLOBE NEWSWIRE) - Fondacioni Global i Sindrom\u00ebs Down (GLOBAL) \u00ebsht\u00eb krenar t\u00eb mb\u00ebshtes\u00eb nj\u00eb\u00a0studim i ri<\/a>\u00a0botuar n\u00eb\u00a0eLIFE<\/i>\u00a0nga hulumtuesit nga partneri dhe filiali i saj,\u00a0Instituti Linda Crnic p\u00ebr Sindrom\u00ebn Down<\/a>\u00a0(Instituti Crnic) n\u00eb\u00a0Kampusi Mjek\u00ebsor i Universitetit t\u00eb Kolorados Anschutz,<\/a>\u00a0q\u00eb raporton rezultatet fillestare t\u00eb nj\u00eb sprove klinike t\u00eb par\u00eb n\u00eb llojin q\u00eb teston sigurin\u00eb dhe efikasitetin e nj\u00eb frenuesi JAK p\u00ebr t\u00eb ulur barr\u00ebn e kushteve autoimune tek njer\u00ebzit me sindrom\u00ebn Down. Prova klinike, e cila financohet nga Instituti Komb\u00ebtar i Artritit dhe S\u00ebmundjeve Muskuloskeletore dhe t\u00eb L\u00ebkur\u00ebs, \u00ebsht\u00eb pjes\u00eb e nj\u00eb portofoli t\u00eb provave t\u00eb reja klinike t\u00eb mb\u00ebshtetura nga Instituti Komb\u00ebtar i Sh\u00ebndetit.\u00a0P\u00cbRFSHIJ Projektin<\/a>.<\/p>\n

Duke u mb\u00ebshtetur n\u00eb to\u00a0Zbulimi i vitit 2016<\/a>\u00a0se p\u00ebrgjigja e interferonit aktivizohet vazhdimisht te njer\u00ebzit me sindrom\u00ebn Down, ekipi projektoi prov\u00ebn p\u00ebr t'u fokusuar n\u00eb kushtet autoimune dhe inflamatore t\u00eb l\u00ebkur\u00ebs q\u00eb jan\u00eb shum\u00eb t\u00eb zakonshme tek njer\u00ebzit me sindrom\u00ebn Down, duke p\u00ebrfshir\u00eb alopecia areata, psoriasis, dermatit atopik dhe hidradenitis suppurativa, dhe p\u00ebrdori frenuesin JAK tofacitinib (t\u00eb tregtuar si XELJANZ\u00ae<\/sup>, Pfizer). Studimi gjithashtu monitoroi efektet n\u00eb gjendjet autoimune q\u00eb ndodhin bashk\u00eb, t\u00eb tilla si s\u00ebmundja autoimune e tiroides, s\u00ebmundja celiac dhe artriti.<\/p>\n

"Individ\u00ebt me sindrom\u00ebn Down jan\u00eb n\u00eb nj\u00eb rrezik t\u00eb lart\u00eb t\u00eb zhvillimit t\u00eb kushteve autoimune t\u00eb l\u00ebkur\u00ebs, t\u00eb cilat shpesh jan\u00eb t\u00eb v\u00ebshtira p\u00ebr t'u trajtuar dhe shkaktojn\u00eb shqet\u00ebsim t\u00eb konsideruesh\u00ebm dhe ulin cil\u00ebsin\u00eb e jet\u00ebs s\u00eb tyre," shpjegon Dr. Emily Gurnee, asistent profesor i dermatologjis\u00eb, nj\u00eb nga dermatolog\u00ebt e p\u00ebrfshir\u00eb. n\u00eb studim dhe nj\u00eb hetues kryesor n\u00eb gjyq. "Ekzistojn\u00eb t\u00eb dh\u00ebna t\u00eb kufizuara p\u00ebr t\u00eb udh\u00ebhequr bisedat rreth opsioneve t\u00eb trajtimit p\u00ebr kushtet e l\u00ebkur\u00ebs t\u00eb zakonshme p\u00ebr individ\u00ebt me sindrom\u00ebn Down. Gjetjet nga shkenc\u00ebtar\u00ebt n\u00eb Institutin Crnic mb\u00ebshtesin nocionin se frenuesit JAK jan\u00eb nj\u00eb trajtim i vlefsh\u00ebm jo vet\u00ebm p\u00ebr kushtet e l\u00ebkur\u00ebs, por mund t\u00eb p\u00ebrfitojn\u00eb kushte t\u00eb tjera autoimune t\u00eb p\u00ebrhapura n\u00eb k\u00ebt\u00eb popullat\u00eb.<\/p>\n

\"\"<\/p>\n

Ekipi i studimit v\u00ebzhgoi p\u00ebrmir\u00ebsime t\u00eb r\u00ebnd\u00ebsishme n\u00eb patologjin\u00eb e l\u00ebkur\u00ebs, me rezultatet m\u00eb t\u00eb habitshme t\u00eb v\u00ebrejtura p\u00ebr ata t\u00eb prekur nga alopecia areata, si dhe p\u00ebrmir\u00ebsime n\u00eb artrit dhe ulje t\u00eb biomarker\u00ebve t\u00eb s\u00ebmundjes autoimune t\u00eb tiroides. Shumica e pjes\u00ebmarr\u00ebsve t\u00eb studimit zgjodh\u00ebn t\u00eb q\u00ebndronin n\u00eb ila\u00e7, shpesh p\u00ebrmes recetave jasht\u00eb etiket\u00ebs, pas p\u00ebrfundimit t\u00eb aktiviteteve t\u00eb prov\u00ebs.<\/p>\n

\u201cM\u00eb e r\u00ebnd\u00ebsishmja, ne vum\u00eb re se sh\u00ebnuesit kryesor\u00eb inflamator\u00eb t\u00eb ngritur n\u00eb sindrom\u00ebn Down q\u00eb dihet se shkaktojn\u00eb autoimunitet u ul\u00ebn n\u00eb kufirin normal me k\u00ebt\u00eb ila\u00e7, duke treguar se sistemi imunitar po qet\u00ebsohet nga ky frenues JAK, duke ruajtur funksionin e fort\u00eb imunitar. ,\u201d shpjegon Dr. Joaqu\u00edn Espinosa, drejtor ekzekutiv i Institutit Crnic, profesor i farmakologjis\u00eb dhe nj\u00eb nga drejtori hetuesit n\u00eb provat klinike. "Do t\u00eb nevojiten m\u00eb shum\u00eb t\u00eb dh\u00ebna p\u00ebr t\u00eb p\u00ebrcaktuar profilin e siguris\u00eb s\u00eb frenuesve JAK n\u00eb sindrom\u00ebn Down, dhe ne presim p\u00ebrfundimin e prov\u00ebs dhe analiz\u00ebs s\u00eb t\u00eb dh\u00ebnave t\u00eb plota."<\/p>\n

Studimi gjithashtu raporton karakterizimin m\u00eb t\u00eb thell\u00eb t\u00eb disrregullimit t\u00eb sistemit imunitar karakteristik t\u00eb sindrom\u00ebs Down deri m\u00eb tani p\u00ebrmes analiz\u00ebs s\u00eb t\u00eb dh\u00ebnave klinike dhe bio-shembullave t\u00eb mbledhura nga studimet e vazhdueshme.\u00a0Projekti Human Trisome<\/a>\u00a0studim.<\/p>\n

Ekipi i Institutit Crnic analizoi t\u00eb dh\u00ebnat klinike dhe mostrat e gjakut p\u00ebr t\u00eb karakterizuar modelin e kushteve autoimune dhe proceseve inflamatore shoq\u00ebruese n\u00eb qindra pjes\u00ebmarr\u00ebs n\u00eb hulumtim n\u00eb Projektin Human Trisome duke p\u00ebrdorur t\u00eb ashtuquajturat teknologji multi-omics. Ata vun\u00eb re se trefishimi i kromozomit 21, ose trizomia 21, anomalia gjenetike q\u00eb q\u00ebndron n\u00eb baz\u00eb t\u00eb sindrom\u00ebs Down, \u00e7on n\u00eb fillimin e shpejt\u00eb t\u00eb kushteve t\u00eb ndryshme autoimune gjat\u00eb f\u00ebmij\u00ebris\u00eb, s\u00eb bashku me rritjen e niveleve t\u00eb shum\u00eb faktor\u00ebve inflamator\u00eb dhe disrregullimin e fort\u00eb t\u00eb llojeve t\u00eb shumta t\u00eb qelizave imune.<\/p>\n

\u201cNj\u00eb v\u00ebzhgim kryesor \u00ebsht\u00eb se ngritja e sh\u00ebnuesve t\u00eb shumt\u00eb inflamator\u00eb dhe \u00e7rregullimi i t\u00eb gjitha deg\u00ebve t\u00eb sistemit imunitar ndodh q\u00eb n\u00eb mosh\u00eb shum\u00eb t\u00eb hershme, madje edhe para \u00e7do manifestimi klinik t\u00eb autoimunitetit,\u201d thot\u00eb Dr. Matthew Galbraith, asistent profesor i farmakologjis\u00eb, drejtor i Programi i Shkencave t\u00eb t\u00eb Dh\u00ebnave t\u00eb Institutit Crnic dhe bashkautor i studimit. "Kjo tregon p\u00ebr nj\u00eb gjendje konstituive t\u00eb disrregullimit imunitar t\u00eb shkaktuar nga kromozomi shtes\u00eb q\u00eb p\u00ebrfundimisht \u00e7on n\u00eb shfaqjen e kushteve t\u00eb shumta autoimune, me ndryshime n\u00eb koh\u00ebn dhe ashp\u00ebrsin\u00eb midis individ\u00ebve."<\/p>\n

"Q\u00eb nga viti 2016 ne kemi hipotezuar se klasa e barnave t\u00eb njohura si frenues JAK do t\u00eb ofroj\u00eb p\u00ebrfitime terapeutike n\u00eb k\u00ebt\u00eb popullat\u00eb," shpjegon Dr. Angela Rachubinski, asistent profesor i pediatris\u00eb, drejtore e Programit t\u00eb Shkencave Klinike dhe P\u00ebrkthimore n\u00eb Institutin Crnic. autori kryesor i punimit dhe nj\u00eb nga hetuesit kryesor\u00eb n\u00eb gjyq. \u201cMegjith\u00ebse frenuesit JAK jan\u00eb miratuar p\u00ebr nj\u00eb s\u00ebr\u00eb kushtesh autoimune dhe inflamatore n\u00eb popullat\u00ebn e p\u00ebrgjithshme, ky test klinik, i cili filloi aktivitetet n\u00eb vitin 2020, ofron hetimin e par\u00eb sistematik t\u00eb efekteve t\u00eb nj\u00eb frenuesi JAK tek njer\u00ebzit me sindrom\u00ebn Down\u201d.<\/p>\n

Ekipi studimor i Institutit Crnic tashm\u00eb po mbik\u00ebqyr nj\u00eb\u00a0gjyqi i dyt\u00eb<\/a>\u00a0testimi i siguris\u00eb dhe efikasitetit t\u00eb frenuesit JAK n\u00eb lidhje me ila\u00e7et e tjera p\u00ebr trajtimin e gjendjes s\u00eb njohur si\u00a0\u00c7rregullimi i regresionit me sindrom\u00ebn Down<\/a>, dhe a\u00a0gjyqi i tret\u00eb<\/a>\u00a0e fokusuar tek f\u00ebmij\u00ebt me sindrom\u00ebn Down pritet t\u00eb filloj\u00eb rekrutimi n\u00eb fund t\u00eb vitit 2024.<\/p>\n

"Ne u jemi shum\u00eb mir\u00ebnjoh\u00ebs shkenc\u00ebtar\u00ebve dhe mjek\u00ebve n\u00eb Institutin Crnic p\u00ebr k\u00ebrkimin e tyre transformues q\u00eb tashm\u00eb po p\u00ebrkthehet n\u00eb p\u00ebrmir\u00ebsimin e kujdesit mjek\u00ebsor dhe rezultateve sh\u00ebndet\u00ebsore p\u00ebr njer\u00ebzit e mahnitsh\u00ebm me sindrom\u00ebn Down t\u00eb cil\u00ebve u sh\u00ebrbejm\u00eb," thot\u00eb Michelle Sie Whitten, presidente dhe CEO e GLOBAL. "Ne jemi krenar\u00eb q\u00eb puna e avokimit t\u00eb GLOBAL me Kongresin dhe me Institutin Komb\u00ebtar t\u00eb Sh\u00ebndetit (NIH) ka \u00e7uar n\u00eb krijimin e projektit t\u00eb financimit t\u00eb sindrom\u00ebs Down trans-NIH, INCLUDE, q\u00eb garanton k\u00ebt\u00eb dhe shum\u00eb studime t\u00eb tjera novatore dhe prova klinike."<\/p>\n

\u00a0<\/b><\/p>\n

Rreth Fondacionit Global t\u00eb Sindrom\u00ebs Down<\/b><\/p>\n

Fondacioni Global i Sindrom\u00ebs Down (GLOBAL) \u00ebsht\u00eb organizata m\u00eb e madhe jofitimprur\u00ebse n\u00eb SHBA q\u00eb punon p\u00ebr t\u00eb shp\u00ebtuar jet\u00eb dhe p\u00ebr t\u00eb p\u00ebrmir\u00ebsuar n\u00eb m\u00ebnyr\u00eb dramatike rezultatet sh\u00ebndet\u00ebsore p\u00ebr njer\u00ebzit me sindrom\u00ebn Down. GLOBAL ka dhuruar m\u00eb shum\u00eb se $32 milion p\u00ebr t\u00eb krijuar institutin e par\u00eb t\u00eb k\u00ebrkimit t\u00eb sindrom\u00ebs Down q\u00eb mb\u00ebshtet mbi 400 shkenc\u00ebtar\u00eb dhe mbi 2500 pacient\u00eb me sindrom\u00ebn Down nga 33 shtete dhe 10 vende. Duke punuar ngusht\u00eb me Kongresin dhe Institutin Komb\u00ebtar t\u00eb Sh\u00ebndet\u00ebsis\u00eb, GLOBAL \u00ebsht\u00eb organizata kryesore e avokimit n\u00eb SHBA p\u00ebr k\u00ebrkimin dhe kujdesin p\u00ebr sindrom\u00ebn Down. GLOBAL ka nj\u00eb an\u00ebtar\u00ebsim n\u00eb mbi 100 organizata t\u00eb sindrom\u00ebs Down n\u00eb mbar\u00eb bot\u00ebn, dhe \u00ebsht\u00eb pjes\u00eb e nj\u00eb rrjeti t\u00eb Filialeve -\u00a0Instituti Crnic p\u00ebr Sindrom\u00ebn Down<\/a>,\u00a0Qendra Sie p\u00ebr Sindrom\u00ebn Down<\/a>, dhe\u00a0Universiteti i Kolorados Alzheimer dhe Qendra e Njohjes<\/a>\u00a0\u2013 t\u00eb gjitha n\u00eb kampusin mjek\u00ebsor t\u00eb Anschutz.<\/p>\n

Publikimet mjek\u00ebsore t\u00eb p\u00ebrhapura gjer\u00ebsisht t\u00eb GLOBAL p\u00ebrfshijn\u00eb\u00a0Udh\u00ebzimet globale t\u00eb kujdesit mjek\u00ebsor p\u00ebr t\u00eb rriturit me sindrom\u00ebn Down<\/i><\/a>,\u00a0Informacion p\u00ebr Sindrom\u00ebn Down para lindjes dhe t\u00eb porsalindurit<\/i><\/a>, dhe revist\u00ebn e vler\u00ebsuar me \u00e7mime\u00a0Down Syndrome World TM<\/i><\/a>. GLOBAL gjithashtu organizon\u00a0B\u00ebhu i Bukur Behu Vet\u00eb Show Fashion<\/i><\/a>, mbledhja m\u00eb e madhe e fondeve p\u00ebr sindrom\u00ebn Down n\u00eb bot\u00eb. Vizitoni\u00a0globaldownsyndrome.org<\/a>\u00a0dhe na ndiqni n\u00eb rrjetet sociale\u00a0Facebook<\/a>,\u00a0X<\/a>\u00a0dhe\u00a0Instagram<\/a>.<\/p>\n

Rreth Institutit Linda Crnic p\u00ebr Sindrom\u00ebn Down<\/b><\/p>\n

Instituti Linda Crnic p\u00ebr Sindrom\u00ebn Down \u00ebsht\u00eb nj\u00eb nga t\u00eb vetmet qendra k\u00ebrkimore akademike t\u00eb p\u00ebrkushtuara plot\u00ebsisht ndaj p\u00ebrmir\u00ebsimit t\u00eb jet\u00ebs s\u00eb njer\u00ebzve me sindrom\u00ebn Down p\u00ebrmes k\u00ebrkimeve t\u00eb avancuara biomjek\u00ebsore, q\u00eb shtrihen nga shkenca baz\u00eb deri tek hetimet p\u00ebrkthimore dhe klinike. I themeluar p\u00ebrmes mb\u00ebshtetjes bujare dhe partneritetit t\u00eb Fondacionit Global t\u00eb Sindrom\u00ebs Down, Fondacionit Anna dhe John J. Sie dhe Universitetit t\u00eb Kolorados, Instituti Crnic mb\u00ebshtet nj\u00eb program t\u00eb lul\u00ebzuar k\u00ebrkimor p\u00ebr sindrom\u00ebn Down q\u00eb p\u00ebrfshin mbi 50 ekipe k\u00ebrkimore n\u00eb kat\u00ebr kampuse n\u00eb Kolorado. Gama e p\u00ebrparme. P\u00ebr t\u00eb m\u00ebsuar m\u00eb shum\u00eb, vizitoni\u00a0www.crnicinstitute.org<\/a>\u00a0ose na ndiqni n\u00eb Facebook dhe Twitter @CrnicInstitute.<\/p>\n

Rreth Kampusit Mjek\u00ebsor t\u00eb Universitetit t\u00eb Kolorados Anschutz<\/b><\/p>\n

Kampusi Mjek\u00ebsor i Universitetit t\u00eb Kolorados Anschutz \u00ebsht\u00eb nj\u00eb destinacion mjek\u00ebsor i klasit bot\u00ebror n\u00eb ball\u00eb t\u00eb shkenc\u00ebs transformuese, mjek\u00ebsis\u00eb, edukimit dhe kujdesit p\u00ebr pacient\u00ebt. Kampusi p\u00ebrfshin shkollat profesionale sh\u00ebndet\u00ebsore t\u00eb Universitetit t\u00eb Kolorados, m\u00eb shum\u00eb se 60 qendra dhe institute dhe dy spitale t\u00eb pavarura t\u00eb renditura n\u00eb nivel komb\u00ebtar -\u00a0UCHealth University of Spitali i Kolorados<\/a>\u00a0dhe\u00a0Spitali i F\u00ebmij\u00ebve n\u00eb Kolorado<\/a>\u00a0\u2013 t\u00eb cilat shohin m\u00eb shum\u00eb se 2 milion\u00eb vizita t\u00eb pacient\u00ebve t\u00eb rritur dhe pediatrik\u00eb \u00e7do vit. Inovativ, i nd\u00ebrlidhur dhe shum\u00eb bashk\u00ebpunues, Kampusi Mjek\u00ebsor i Universitetit t\u00eb Kolorados Anschutz ofron trajtime q\u00eb ndryshojn\u00eb jet\u00ebn, kujdes p\u00ebr pacient\u00ebt dhe trajnim profesional dhe kryen k\u00ebrkime t\u00eb njohura bot\u00ebrore t\u00eb nxitura nga $705 milion grante k\u00ebrkimore. P\u00ebr m\u00eb shum\u00eb informacion, vizitoni\u00a0www.cuanschutz.edu<\/a>.<\/p>\n

###<\/p>","protected":false},"excerpt":{"rendered":"

Denver, Aug. 13, 2024 (GLOBE NEWSWIRE) — The Global Down Syndrome Foundation (GLOBAL) is proud to support a\u00a0new study\u00a0published in\u00a0eLIFE\u00a0by researchers from its partner and Affiliate, the\u00a0Linda Crnic Institute for Down Syndrome\u00a0(Crnic Institute) at the\u00a0University of Colorado Anschutz Medical Campus,\u00a0that reports the initial results of a first-in-kind clinical trial testing the safety and efficacy of […]<\/p>\n","protected":false},"author":3,"featured_media":157306,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"ngg_post_thumbnail":0,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-157305","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-releases"],"acf":[],"yoast_head":"\nCrnic Institute Clinical Trial Shows JAK Inhibitor Improves Multiple Autoimmune Conditions in Patients with Down Syndrome | Global Down Syndrome Foundation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.globaldownsyndrome.org\/sq\/studimi-klinik-i-institutit-crnic-tregon-se-frenuesi-jak-permireson-gjendjet-e-shumta-autoimune-ne-pacientet-me-sindromen-down\/\" \/>\n<meta property=\"og:locale\" content=\"sq_AL\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Crnic Institute Clinical Trial Shows JAK Inhibitor Improves Multiple Autoimmune Conditions in Patients with Down Syndrome | Global Down Syndrome Foundation\" \/>\n<meta property=\"og:description\" content=\"Denver, Aug. 13, 2024 (GLOBE NEWSWIRE) — The Global Down Syndrome Foundation (GLOBAL) is proud to support a\u00a0new study\u00a0published in\u00a0eLIFE\u00a0by researchers from its partner and Affiliate, the\u00a0Linda Crnic Institute for Down Syndrome\u00a0(Crnic Institute) at the\u00a0University of Colorado Anschutz Medical Campus,\u00a0that reports the initial results of a first-in-kind clinical trial testing the safety and efficacy of […]\" \/>\n<meta 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