{"id":152841,"date":"2023-08-31T09:10:04","date_gmt":"2023-08-31T15:10:04","guid":{"rendered":"https:\/\/www.globaldownsyndrome.org\/?p=152841"},"modified":"2023-08-31T09:12:19","modified_gmt":"2023-08-31T15:12:19","slug":"scientists-reveal-the-harmful-impacts-of-immune-hyperactivity-in-down-syndrome-and-how-to-normalize-it-by-repurposing-existing-drugs","status":"publish","type":"post","link":"https:\/\/www.globaldownsyndrome.org\/sw\/scientists-reveal-the-harmful-impacts-of-immune-hyperactivity-in-down-syndrome-and-how-to-normalize-it-by-repurposing-existing-drugs\/","title":{"rendered":"Scientists Reveal the Harmful Impacts of Immune Hyperactivity in Down Syndrome and How to Normalize it by Repurposing Existing Drugs"},"content":{"rendered":"

In a new study, scientists at the University of Colorado Anschutz Medical Campus report the largest and deepest characterization of immune dysregulation in Down syndrome to date<\/p>\n

AURORA, CO (July 23, 2023) \u2013 <\/strong>People with Down syndrome, the condition caused by an extra copy of chromosome 21, or trisomy 21, display chronic dysregulation of their immune system, which can contribute to high rates of autoimmune conditions and severe complications from respiratory infections.<\/p>\n

In a new study<\/a> published in Science Advances, scientists at the Linda Crnic Institute for Down Syndrome at the University of Colorado Anschutz Medical Campus report the largest and deepest characterization of immune dysregulation in Down syndrome to date. The findings also reveal important connections between immune hyperactivity and other aspects of Down syndrome and provide proof-of-principle evidence for a therapeutic strategy to restore immune balance in this population.<\/p>\n

The Crnic Institute\u2019s previous research<\/a> demonstrated that this immune dysregulation is associated with hyperactivity in the interferon response, the main defense against viruses. In addition, they showed interferon hyperactivity contributes to many hallmarks of Down syndrome in a mouse model<\/a>, including congenital heart defects, developmental delays, cognitive impairments and malformation of the bone structures in the skull.<\/p>\n

The most recent study reports the analysis of hundreds of blood samples from research participants enrolled in the Crnic Institute Human Trisome Project<\/a>, a large cohort study of people with Down syndrome. Using a combination of large-scale data technologies, referred to as multi-omics, they defined associations between the degree of interferon hyperactivity and multiple physiological, metabolic, and immune processes dysregulated by the extra chromosome.<\/p>\n

\u201cWe observed that interferon hyperactivity really shapes the biology of Down syndrome across the lifespan. Those with the highest interferon activity display increased signs of autoinflammation, stronger dysregulation of important growth factors, profound metabolic changes, and a vastly different immune system,\u201d says Dr. Matthew Galbraith, leader of the Data Sciences Program at the Crnic Institute and one of the co-leading authors of the paper.<\/p>\n

\u201cThese results clearly demonstrate that persons with Down syndrome with the highest levels of interferon activity show drastic changes in the immune system, such as increases in a type of T cells often involved in the development of autoimmune conditions, or depletion of B cells, which are important for response to vaccines\u201d explains Keith Smith, co-leading author of the paper.<\/p>\n

Previous studies have indicated that interferon hyperactivity could be ameliorated with a class of drugs known as \u201cJAK inhibitors\u201d which are approved for the treatment of a wide range of autoinflammatory conditions in the general population. However, the effects of JAK inhibitors on the biological processes modulated by trisomy 21 have not been extensively studied.<\/p>\n

To advance this area of research, the Crnic Institute team monitored the effects of JAK inhibition on a research participant with Down syndrome taking the JAK inhibitor known as tofacitinib, or Xeljanz\u2122, for the treatment of alopecia areata. Alopecia areata is an autoimmune form of hair loss more common in people with Down syndrome. Over the course of several years and under the care of their dermatologist, the participant provided blood samples while on the medicine and during voluntary interruptions of the treatment.<\/p>\n

\u201cWe observed a remarkable normalization of interferon hyperactivity when the participant was taking the JAK inhibitor. Consistently, her interferon metrics and other biomarkers of inflammation dropped from the abnormally high levels seen in Down syndrome down to the range observed in the general population, but not any lower. This indicates that the JAK inhibitor provided therapeutic benefit in terms of hair regrowth without suppressing the immune system below the normal range,\u201d explains Dr. Angela Rachubinski, leader of the Clinical and Translational Sciences Program at the Crnic Institute and co-lead author of the study.<\/p>\n

According to Dr. Joaquin Espinosa, executive director of the Crnic Institute and senior author of the paper, this study provided the rationale for two additional clinical trials for JAK inhibition in Down syndrome led by the Crnic Institute. \u201cOne study is focused on autoimmune skin conditions<\/a> and another one is focused on Down Syndrome Regression Disorder, a rare but devastating condition characterized by sudden loss of  daily living skills and cognitive abilities.\u201d<\/p>\n

\u201cThis study is an example of the transformative scientific research taking place today that is enabled by increased funding from the National Institutes of Health through the INCLUDE Project, which in turn is the fruit of many years of advocacy and strong support from members of Congress. Naturally, none of these discoveries would be possible without the enthusiastic participation of our self-advocates and their families in research projects like the Human Trisome Project,\u201d says Michelle Sie Whitten, president and CEO of the Global Down Syndrome Foundation<\/a>, which supported the project with funding and outreach.<\/p>\n

 <\/p>\n

# # # <\/p>\n

About the University of Colorado Anschutz Medical Campus<\/strong><\/p>\n

The University of Colorado Anschutz Medical Campus is a world-class medical destination at the forefront of transformative science, medicine, education and patient care. The campus encompasses the University of Colorado health professional schools, more than 60 centers and institutes and two nationally ranked independent hospitals – UCHealth University of Colorado Hospital<\/a> na Children’s Hospital Colorado<\/a> – that treat more than two million adult and pediatric patients each year. Innovative, interconnected and highly collaborative, the University of Colorado Anschutz Medical Campus delivers life-changing treatments, patient care and professional training and conducts world-renowned research fueled by over $690 million in research grants. For more information, visit www.cuanschutz.edu<\/a>.<\/p>\n

Kuhusu Taasisi ya Linda Crnic ya Ugonjwa wa Down<\/strong><\/p>\n

The Linda Crnic Institute for Down Syndrome is one of the only academic research centers fully devoted to improving the lives of people with Down syndrome through advanced biomedical research, spanning from basic science to translational and clinical investigations. Founded through the generous support and partnership of the Global Down Syndrome Foundation, the Anna and John J. Sie Foundation, and the University of Colorado, the Crnic Institute supports a thriving Down syndrome research program involving over 50 research teams across four campuses on the Colorado Front Range. To learn more, visit www.crnicinstitute.org<\/a> or follow us on Facebook and Twitter @CrnicInstitute.<\/p>\n

Kuhusu Global Down Syndrome Foundation<\/strong><\/p>\n

The Global Down Syndrome Foundation (GLOBAL) is the largest non-profit in the U.S. working to save lives and dramatically improve health outcomes for people with Down syndrome. GLOBAL has donated more than $32 million to establish the first Down syndrome research institute supporting over 400 scientists and over 2,200 patients with Down syndrome from 33 states and 10 countries. Working closely with Congress and the National Institutes of Health, GLOBAL is the lead advocacy organization in the U.S. for Down syndrome research and care. GLOBAL has a membership of over 120 Down syndrome organizations worldwide, and is part of a network of Affiliates \u2013 the Taasisi ya Crnic ya Ugonjwa wa Chini<\/a>,, Sie Center for Down Syndrome<\/a>, na Chuo Kikuu cha Colorado Alzheimer's and Cognition Center<\/a> \u2013 all on the Anschutz Medical Campus.<\/p>\n

Machapisho ya matibabu yanayosambazwa sana ya GLOBAL ni pamoja na Mwongozo wa Kimataifa wa Huduma ya Kimatibabu kwa Watu Wazima wenye Ugonjwa wa Kupungua<\/em><\/a>, Upimaji wa kabla ya kuzaa na Habari kuhusu Down Syndrome<\/em><\/a>, na jarida lililoshinda tuzo Ulimwengu wa Down Syndrome TM<\/sup><\/em><\/a> . GLOBAL also organizes the Kuwa Mrembo Uwe Mwenyewe Onyesho la Mitindo<\/em><\/a>, the largest Down syndrome fundraiser in the world.<\/p>\n

Visit globaldownsyndrome.org and follow us on social media (Facebook & Twitter: @GDSFoundation, Instagram: @globaldownsyndrome).<\/p>","protected":false},"excerpt":{"rendered":"

In a new study, scientists at the University of Colorado Anschutz Medical Campus report the largest and deepest characterization of immune dysregulation in Down syndrome to date AURORA, CO (July 23, 2023) \u2013 People with Down syndrome, the condition caused by an extra copy of chromosome 21, or trisomy 21, display chronic dysregulation of their […]<\/p>\n","protected":false},"author":3,"featured_media":152842,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"ngg_post_thumbnail":0,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-152841","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-releases"],"acf":[],"yoast_head":"\nScientists Reveal the Harmful Impacts of Immune Hyperactivity in Down Syndrome and How to Normalize it by Repurposing Existing Drugs | Global Down Syndrome Foundation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.globaldownsyndrome.org\/sw\/scientists-reveal-the-harmful-impacts-of-immune-hyperactivity-in-down-syndrome-and-how-to-normalize-it-by-repurposing-existing-drugs\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Scientists Reveal the Harmful Impacts of Immune Hyperactivity in Down Syndrome and How to Normalize it by Repurposing Existing Drugs | Global Down Syndrome Foundation\" \/>\n<meta property=\"og:description\" content=\"In a new study, scientists at the University of Colorado Anschutz Medical Campus report the largest and deepest characterization of immune dysregulation in Down syndrome to date AURORA, CO (July 23, 2023) \u2013 People with Down syndrome, the condition caused by an extra copy of chromosome 21, or trisomy 21, display chronic dysregulation of their […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.globaldownsyndrome.org\/sw\/scientists-reveal-the-harmful-impacts-of-immune-hyperactivity-in-down-syndrome-and-how-to-normalize-it-by-repurposing-existing-drugs\/\" \/>\n<meta property=\"og:site_name\" content=\"Global Down Syndrome Foundation\" \/>\n<meta property=\"article:published_time\" content=\"2023-08-31T15:10:04+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-08-31T15:12:19+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globaldownsyndrome.org\/wp-content\/uploads\/2023\/08\/CU-Logo.png\" \/>\n\t<meta property=\"og:image:width\" content=\"341\" \/>\n\t<meta property=\"og:image:height\" content=\"148\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Global Down Syndrome Foundation\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Global Down Syndrome Foundation\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"dakika 6\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.globaldownsyndrome.org\\\/scientists-reveal-the-harmful-impacts-of-immune-hyperactivity-in-down-syndrome-and-how-to-normalize-it-by-repurposing-existing-drugs\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.globaldownsyndrome.org\\\/scientists-reveal-the-harmful-impacts-of-immune-hyperactivity-in-down-syndrome-and-how-to-normalize-it-by-repurposing-existing-drugs\\\/\"},\"author\":{\"name\":\"Global Down Syndrome Foundation\",\"@id\":\"https:\\\/\\\/www.globaldownsyndrome.org\\\/#\\\/schema\\\/person\\\/c7b9993b5c3546494cff0579493fcfa6\"},\"headline\":\"Scientists Reveal the Harmful Impacts of Immune Hyperactivity in Down Syndrome and How to Normalize it by Repurposing Existing Drugs\",\"datePublished\":\"2023-08-31T15:10:04+00:00\",\"dateModified\":\"2023-08-31T15:12:19+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.globaldownsyndrome.org\\\/scientists-reveal-the-harmful-impacts-of-immune-hyperactivity-in-down-syndrome-and-how-to-normalize-it-by-repurposing-existing-drugs\\\/\"},\"wordCount\":1229,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/www.globaldownsyndrome.org\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.globaldownsyndrome.org\\\/scientists-reveal-the-harmful-impacts-of-immune-hyperactivity-in-down-syndrome-and-how-to-normalize-it-by-repurposing-existing-drugs\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globaldownsyndrome.org\\\/wp-content\\\/uploads\\\/2023\\\/08\\\/CU-Logo.png\",\"articleSection\":[\"Press Releases\"],\"inLanguage\":\"sw\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/www.globaldownsyndrome.org\\\/scientists-reveal-the-harmful-impacts-of-immune-hyperactivity-in-down-syndrome-and-how-to-normalize-it-by-repurposing-existing-drugs\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.globaldownsyndrome.org\\\/scientists-reveal-the-harmful-impacts-of-immune-hyperactivity-in-down-syndrome-and-how-to-normalize-it-by-repurposing-existing-drugs\\\/\",\"url\":\"https:\\\/\\\/www.globaldownsyndrome.org\\\/scientists-reveal-the-harmful-impacts-of-immune-hyperactivity-in-down-syndrome-and-how-to-normalize-it-by-repurposing-existing-drugs\\\/\",\"name\":\"Scientists Reveal the Harmful Impacts of Immune Hyperactivity in Down Syndrome and How to Normalize it by Repurposing Existing Drugs | Global Down Syndrome Foundation\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.globaldownsyndrome.org\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.globaldownsyndrome.org\\\/scientists-reveal-the-harmful-impacts-of-immune-hyperactivity-in-down-syndrome-and-how-to-normalize-it-by-repurposing-existing-drugs\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.globaldownsyndrome.org\\\/scientists-reveal-the-harmful-impacts-of-immune-hyperactivity-in-down-syndrome-and-how-to-normalize-it-by-repurposing-existing-drugs\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globaldownsyndrome.org\\\/wp-content\\\/uploads\\\/2023\\\/08\\\/CU-Logo.png\",\"datePublished\":\"2023-08-31T15:10:04+00:00\",\"dateModified\":\"2023-08-31T15:12:19+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.globaldownsyndrome.org\\\/scientists-reveal-the-harmful-impacts-of-immune-hyperactivity-in-down-syndrome-and-how-to-normalize-it-by-repurposing-existing-drugs\\\/#breadcrumb\"},\"inLanguage\":\"sw\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.globaldownsyndrome.org\\\/scientists-reveal-the-harmful-impacts-of-immune-hyperactivity-in-down-syndrome-and-how-to-normalize-it-by-repurposing-existing-drugs\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"sw\",\"@id\":\"https:\\\/\\\/www.globaldownsyndrome.org\\\/scientists-reveal-the-harmful-impacts-of-immune-hyperactivity-in-down-syndrome-and-how-to-normalize-it-by-repurposing-existing-drugs\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.globaldownsyndrome.org\\\/wp-content\\\/uploads\\\/2023\\\/08\\\/CU-Logo.png\",\"contentUrl\":\"https:\\\/\\\/www.globaldownsyndrome.org\\\/wp-content\\\/uploads\\\/2023\\\/08\\\/CU-Logo.png\",\"width\":341,\"height\":148},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.globaldownsyndrome.org\\\/scientists-reveal-the-harmful-impacts-of-immune-hyperactivity-in-down-syndrome-and-how-to-normalize-it-by-repurposing-existing-drugs\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.globaldownsyndrome.org\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Scientists Reveal the Harmful Impacts of Immune Hyperactivity in Down Syndrome and How to Normalize it by Repurposing Existing Drugs\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.globaldownsyndrome.org\\\/#website\",\"url\":\"https:\\\/\\\/www.globaldownsyndrome.org\\\/\",\"name\":\"Global Down Syndrome Foundation\",\"description\":\"Dedicated to significantly improving the lives of people with Down Syndrome through RESEARCH, MEDICAL CARE, EDUCATION AND ADVOCACY\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.globaldownsyndrome.org\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.globaldownsyndrome.org\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"sw\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.globaldownsyndrome.org\\\/#organization\",\"name\":\"Global Down Syndrome Foundation\",\"url\":\"https:\\\/\\\/www.globaldownsyndrome.org\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"sw\",\"@id\":\"https:\\\/\\\/www.globaldownsyndrome.org\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.globaldownsyndrome.org\\\/wp-content\\\/uploads\\\/2022\\\/11\\\/logo.jpg\",\"contentUrl\":\"https:\\\/\\\/www.globaldownsyndrome.org\\\/wp-content\\\/uploads\\\/2022\\\/11\\\/logo.jpg\",\"width\":2351,\"height\":896,\"caption\":\"Global Down Syndrome Foundation\"},\"image\":{\"@id\":\"https:\\\/\\\/www.globaldownsyndrome.org\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.globaldownsyndrome.org\\\/#\\\/schema\\\/person\\\/c7b9993b5c3546494cff0579493fcfa6\",\"name\":\"Global Down Syndrome Foundation\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Scientists Reveal the Harmful Impacts of Immune Hyperactivity in Down Syndrome and How to Normalize it by Repurposing Existing Drugs | Global Down Syndrome Foundation","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.globaldownsyndrome.org\/sw\/scientists-reveal-the-harmful-impacts-of-immune-hyperactivity-in-down-syndrome-and-how-to-normalize-it-by-repurposing-existing-drugs\/","og_locale":"en_US","og_type":"article","og_title":"Scientists Reveal the Harmful Impacts of Immune Hyperactivity in Down Syndrome and How to Normalize it by Repurposing Existing Drugs | Global Down Syndrome Foundation","og_description":"In a new study, scientists at the University of Colorado Anschutz Medical Campus report the largest and deepest characterization of immune dysregulation in Down syndrome to date AURORA, CO (July 23, 2023) \u2013 People with Down syndrome, the condition caused by an extra copy of chromosome 21, or trisomy 21, display chronic dysregulation of their […]","og_url":"https:\/\/www.globaldownsyndrome.org\/sw\/scientists-reveal-the-harmful-impacts-of-immune-hyperactivity-in-down-syndrome-and-how-to-normalize-it-by-repurposing-existing-drugs\/","og_site_name":"Global Down Syndrome Foundation","article_published_time":"2023-08-31T15:10:04+00:00","article_modified_time":"2023-08-31T15:12:19+00:00","og_image":[{"width":341,"height":148,"url":"https:\/\/www.globaldownsyndrome.org\/wp-content\/uploads\/2023\/08\/CU-Logo.png","type":"image\/png"}],"author":"Global Down Syndrome Foundation","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Global Down Syndrome Foundation","Est. reading time":"dakika 6"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.globaldownsyndrome.org\/scientists-reveal-the-harmful-impacts-of-immune-hyperactivity-in-down-syndrome-and-how-to-normalize-it-by-repurposing-existing-drugs\/#article","isPartOf":{"@id":"https:\/\/www.globaldownsyndrome.org\/scientists-reveal-the-harmful-impacts-of-immune-hyperactivity-in-down-syndrome-and-how-to-normalize-it-by-repurposing-existing-drugs\/"},"author":{"name":"Global Down Syndrome Foundation","@id":"https:\/\/www.globaldownsyndrome.org\/#\/schema\/person\/c7b9993b5c3546494cff0579493fcfa6"},"headline":"Scientists Reveal the Harmful Impacts of Immune Hyperactivity in Down Syndrome and How to Normalize it by Repurposing Existing Drugs","datePublished":"2023-08-31T15:10:04+00:00","dateModified":"2023-08-31T15:12:19+00:00","mainEntityOfPage":{"@id":"https:\/\/www.globaldownsyndrome.org\/scientists-reveal-the-harmful-impacts-of-immune-hyperactivity-in-down-syndrome-and-how-to-normalize-it-by-repurposing-existing-drugs\/"},"wordCount":1229,"commentCount":0,"publisher":{"@id":"https:\/\/www.globaldownsyndrome.org\/#organization"},"image":{"@id":"https:\/\/www.globaldownsyndrome.org\/scientists-reveal-the-harmful-impacts-of-immune-hyperactivity-in-down-syndrome-and-how-to-normalize-it-by-repurposing-existing-drugs\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globaldownsyndrome.org\/wp-content\/uploads\/2023\/08\/CU-Logo.png","articleSection":["Press Releases"],"inLanguage":"sw","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/www.globaldownsyndrome.org\/scientists-reveal-the-harmful-impacts-of-immune-hyperactivity-in-down-syndrome-and-how-to-normalize-it-by-repurposing-existing-drugs\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/www.globaldownsyndrome.org\/scientists-reveal-the-harmful-impacts-of-immune-hyperactivity-in-down-syndrome-and-how-to-normalize-it-by-repurposing-existing-drugs\/","url":"https:\/\/www.globaldownsyndrome.org\/scientists-reveal-the-harmful-impacts-of-immune-hyperactivity-in-down-syndrome-and-how-to-normalize-it-by-repurposing-existing-drugs\/","name":"Scientists Reveal the Harmful Impacts of Immune Hyperactivity in Down Syndrome and How to Normalize it by Repurposing Existing Drugs | Global Down Syndrome Foundation","isPartOf":{"@id":"https:\/\/www.globaldownsyndrome.org\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.globaldownsyndrome.org\/scientists-reveal-the-harmful-impacts-of-immune-hyperactivity-in-down-syndrome-and-how-to-normalize-it-by-repurposing-existing-drugs\/#primaryimage"},"image":{"@id":"https:\/\/www.globaldownsyndrome.org\/scientists-reveal-the-harmful-impacts-of-immune-hyperactivity-in-down-syndrome-and-how-to-normalize-it-by-repurposing-existing-drugs\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globaldownsyndrome.org\/wp-content\/uploads\/2023\/08\/CU-Logo.png","datePublished":"2023-08-31T15:10:04+00:00","dateModified":"2023-08-31T15:12:19+00:00","breadcrumb":{"@id":"https:\/\/www.globaldownsyndrome.org\/scientists-reveal-the-harmful-impacts-of-immune-hyperactivity-in-down-syndrome-and-how-to-normalize-it-by-repurposing-existing-drugs\/#breadcrumb"},"inLanguage":"sw","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.globaldownsyndrome.org\/scientists-reveal-the-harmful-impacts-of-immune-hyperactivity-in-down-syndrome-and-how-to-normalize-it-by-repurposing-existing-drugs\/"]}]},{"@type":"ImageObject","inLanguage":"sw","@id":"https:\/\/www.globaldownsyndrome.org\/scientists-reveal-the-harmful-impacts-of-immune-hyperactivity-in-down-syndrome-and-how-to-normalize-it-by-repurposing-existing-drugs\/#primaryimage","url":"https:\/\/www.globaldownsyndrome.org\/wp-content\/uploads\/2023\/08\/CU-Logo.png","contentUrl":"https:\/\/www.globaldownsyndrome.org\/wp-content\/uploads\/2023\/08\/CU-Logo.png","width":341,"height":148},{"@type":"BreadcrumbList","@id":"https:\/\/www.globaldownsyndrome.org\/scientists-reveal-the-harmful-impacts-of-immune-hyperactivity-in-down-syndrome-and-how-to-normalize-it-by-repurposing-existing-drugs\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.globaldownsyndrome.org\/"},{"@type":"ListItem","position":2,"name":"Scientists Reveal the Harmful Impacts of Immune Hyperactivity in Down Syndrome and How to Normalize it by Repurposing Existing Drugs"}]},{"@type":"WebSite","@id":"https:\/\/www.globaldownsyndrome.org\/#website","url":"https:\/\/www.globaldownsyndrome.org\/","name":"Global Down Syndrome Foundation","description":"Imejitolea kuboresha kwa kiasi kikubwa maisha ya watu wenye Down Syndrome kupitia UTAFITI, HUDUMA ZA MATIBABU, ELIMU NA UTETEZI.","publisher":{"@id":"https:\/\/www.globaldownsyndrome.org\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.globaldownsyndrome.org\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"sw"},{"@type":"Organization","@id":"https:\/\/www.globaldownsyndrome.org\/#organization","name":"Global Down Syndrome Foundation","url":"https:\/\/www.globaldownsyndrome.org\/","logo":{"@type":"ImageObject","inLanguage":"sw","@id":"https:\/\/www.globaldownsyndrome.org\/#\/schema\/logo\/image\/","url":"https:\/\/www.globaldownsyndrome.org\/wp-content\/uploads\/2022\/11\/logo.jpg","contentUrl":"https:\/\/www.globaldownsyndrome.org\/wp-content\/uploads\/2022\/11\/logo.jpg","width":2351,"height":896,"caption":"Global Down Syndrome Foundation"},"image":{"@id":"https:\/\/www.globaldownsyndrome.org\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/www.globaldownsyndrome.org\/#\/schema\/person\/c7b9993b5c3546494cff0579493fcfa6","name":"Global Down Syndrome Foundation"}]}},"jetpack_featured_media_url":"https:\/\/www.globaldownsyndrome.org\/wp-content\/uploads\/2023\/08\/CU-Logo.png","jetpack_shortlink":"https:\/\/wp.me\/p70gmm-DLb","jetpack-related-posts":[{"id":157305,"url":"https:\/\/www.globaldownsyndrome.org\/sw\/crnic-institute-clinical-trial-shows-jak-inhibitor-improves-multiple-autoimmune-conditions-in-patients-with-down-syndrome\/","url_meta":{"origin":152841,"position":0},"title":"Crnic Institute Clinical Trial Shows JAK Inhibitor Improves Multiple Autoimmune Conditions in Patients with Down Syndrome","author":"Global Down Syndrome Foundation","date":"Agosti 13, 2024","format":false,"excerpt":"Denver, Aug. 13, 2024 (GLOBE NEWSWIRE) -- The Global Down Syndrome Foundation (GLOBAL) is proud to support a\u00a0new study\u00a0published in\u00a0eLIFE\u00a0by researchers from its partner and Affiliate, the\u00a0Linda Crnic Institute for Down Syndrome\u00a0(Crnic Institute) at the\u00a0University of Colorado Anschutz Medical Campus,\u00a0that reports the initial results of a first-in-kind clinical trial testing\u2026","rel":"","context":"In "Press Releases"","block_context":{"text":"Press Releases","link":"https:\/\/www.globaldownsyndrome.org\/sw\/category\/press-releases\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/www.globaldownsyndrome.org\/wp-content\/uploads\/2024\/08\/Picture-for-release.png?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/www.globaldownsyndrome.org\/wp-content\/uploads\/2024\/08\/Picture-for-release.png?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/www.globaldownsyndrome.org\/wp-content\/uploads\/2024\/08\/Picture-for-release.png?resize=525%2C300&ssl=1 1.5x"},"classes":[]},{"id":162030,"url":"https:\/\/www.globaldownsyndrome.org\/sw\/crnic-institute-breakthrough-maps-how-down-syndrome-biology-changes-with-age\/","url_meta":{"origin":152841,"position":1},"title":"Crnic Institute Breakthrough Maps How Down Syndrome Biology Changes with Age","author":"Alex Lee","date":"Septemba 25, 2025","format":false,"excerpt":"New study in Nature Communications highlights need for personalized medicine tailored to different life stages in individuals with Down syndrome AURORA, Colo. (Sept. 25, 2025) \u2013 In a groundbreaking new study published in\u00a0Nature Communications, researchers from the Linda Crnic Institute for Down Syndrome (Crnic Institute) at the University of Colorado\u2026","rel":"","context":"In "Blog"","block_context":{"text":"Blog","link":"https:\/\/www.globaldownsyndrome.org\/sw\/category\/blog\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/www.globaldownsyndrome.org\/wp-content\/uploads\/2025\/09\/Clinical-3783_websize.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/www.globaldownsyndrome.org\/wp-content\/uploads\/2025\/09\/Clinical-3783_websize.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/www.globaldownsyndrome.org\/wp-content\/uploads\/2025\/09\/Clinical-3783_websize.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/www.globaldownsyndrome.org\/wp-content\/uploads\/2025\/09\/Clinical-3783_websize.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/www.globaldownsyndrome.org\/wp-content\/uploads\/2025\/09\/Clinical-3783_websize.jpg?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/www.globaldownsyndrome.org\/wp-content\/uploads\/2025\/09\/Clinical-3783_websize.jpg?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":151209,"url":"https:\/\/www.globaldownsyndrome.org\/sw\/crnic-institute-acquires-state-of-the-art-research-equipment-thanks-to-congressional-funding-secured-by-rep-crow\/","url_meta":{"origin":152841,"position":2},"title":"Crnic Institute Acquires State-of-the-Art Research Equipment Thanks to Congressional Funding Secured by Rep Crow","author":"Global Down Syndrome Foundation","date":"Aprili 27, 2023","format":false,"excerpt":"New Research Capability Will Accelerate Breakthrough Immune System Dysregulation Research in People with Down Syndrome DENVER \u2013 Thursday, April 27 \u2013 Today, the Global Down Syndrome Foundation (GLOBAL) announced its affiliate, the Linda Crnic Institute for Down Syndrome at the University of Colorado Anschutz Medical Campus (Crnic Institute), has acquired\u2026","rel":"","context":"In "Press Releases"","block_context":{"text":"Press Releases","link":"https:\/\/www.globaldownsyndrome.org\/sw\/category\/press-releases\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/www.globaldownsyndrome.org\/wp-content\/uploads\/2023\/04\/Crnic-Photo1-scaled.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/www.globaldownsyndrome.org\/wp-content\/uploads\/2023\/04\/Crnic-Photo1-scaled.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/www.globaldownsyndrome.org\/wp-content\/uploads\/2023\/04\/Crnic-Photo1-scaled.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/www.globaldownsyndrome.org\/wp-content\/uploads\/2023\/04\/Crnic-Photo1-scaled.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/www.globaldownsyndrome.org\/wp-content\/uploads\/2023\/04\/Crnic-Photo1-scaled.jpg?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/www.globaldownsyndrome.org\/wp-content\/uploads\/2023\/04\/Crnic-Photo1-scaled.jpg?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":157333,"url":"https:\/\/www.globaldownsyndrome.org\/sw\/groundbreaking-crnic-institute-study-discovers-differences-in-oxygen-physiology-in-people-with-down-syndrome\/","url_meta":{"origin":152841,"position":3},"title":"Groundbreaking Crnic Institute Study Discovers Differences in Oxygen Physiology in People with Down Syndrome","author":"Global Down Syndrome Foundation","date":"Agosti 15, 2024","format":false,"excerpt":"Denver, Aug. 15, 2024 (GLOBE NEWSWIRE) --\u00a0A groundbreaking new study published in\u00a0Cell Reports\u00a0by researchers from the Linda Crnic Institute for Down Syndrome (Crnic Institute) at the University of Colorado Anschutz Medical Campus reports important differences in oxygen physiology and red blood cell function in individuals with Down syndrome. The study\u2026","rel":"","context":"In "Press Releases"","block_context":{"text":"Press Releases","link":"https:\/\/www.globaldownsyndrome.org\/sw\/category\/press-releases\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/www.globaldownsyndrome.org\/wp-content\/uploads\/2024\/08\/GLOBAL-Press-Release-Crnic-Hypoxia-Cell-Reports-Connor-Long-Photo-1-e1723742679536.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/www.globaldownsyndrome.org\/wp-content\/uploads\/2024\/08\/GLOBAL-Press-Release-Crnic-Hypoxia-Cell-Reports-Connor-Long-Photo-1-e1723742679536.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/www.globaldownsyndrome.org\/wp-content\/uploads\/2024\/08\/GLOBAL-Press-Release-Crnic-Hypoxia-Cell-Reports-Connor-Long-Photo-1-e1723742679536.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/www.globaldownsyndrome.org\/wp-content\/uploads\/2024\/08\/GLOBAL-Press-Release-Crnic-Hypoxia-Cell-Reports-Connor-Long-Photo-1-e1723742679536.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/www.globaldownsyndrome.org\/wp-content\/uploads\/2024\/08\/GLOBAL-Press-Release-Crnic-Hypoxia-Cell-Reports-Connor-Long-Photo-1-e1723742679536.jpg?resize=1050%2C600&ssl=1 3x"},"classes":[]},{"id":157130,"url":"https:\/\/www.globaldownsyndrome.org\/sw\/breakthrough-study-reveals-molecular-subtypes-of-down-syndrome-offering-insights-for-personalized-medicine-approaches\/","url_meta":{"origin":152841,"position":4},"title":"Breakthrough Study Reveals Molecular Subtypes of Down Syndrome, Offering Insights for Personalized Medicine Approaches","author":"Global Down Syndrome Foundation","date":"Agosti 7, 2024","format":false,"excerpt":"Denver, Aug 07, 2024 (GLOBE NEWSWIRE) -- Global Down Syndrome Foundation (GLOBAL) is proud to support a new study published in Nature Communications\u00a0by researchers at its partner and Affiliate, the\u00a0Linda Crnic Institute for Down Syndrome\u00a0(Crnic Institute) at the\u00a0University of Colorado Anschutz Medical Campus.\u00a0The breakthrough research, \u00a0part of the ongoing\u00a0Crnic Institute\u2026","rel":"","context":"In "Press Releases"","block_context":{"text":"Press Releases","link":"https:\/\/www.globaldownsyndrome.org\/sw\/category\/press-releases\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/www.globaldownsyndrome.org\/wp-content\/uploads\/2024\/08\/JE-and-David-Eagan-at-NDSC-2024.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/www.globaldownsyndrome.org\/wp-content\/uploads\/2024\/08\/JE-and-David-Eagan-at-NDSC-2024.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/www.globaldownsyndrome.org\/wp-content\/uploads\/2024\/08\/JE-and-David-Eagan-at-NDSC-2024.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/www.globaldownsyndrome.org\/wp-content\/uploads\/2024\/08\/JE-and-David-Eagan-at-NDSC-2024.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":152115,"url":"https:\/\/www.globaldownsyndrome.org\/sw\/scientists-discover-mechanism-affecting-heart-development-in-down-syndrome\/","url_meta":{"origin":152841,"position":5},"title":"Scientists Discover Mechanism Affecting Heart Development in Down Syndrome","author":"Global Down Syndrome Foundation","date":"Julai 18, 2023","format":false,"excerpt":"Research at the University of Colorado Anschutz Medical Campus discovers a molecular mechanism contributing to the development of heart malformations in infants with Down syndrome. From\u00a0Down Syndrome World Issue 2, 2023 Newborns with Down syndrome, a genetic condition resulting from an additional copy of chromosome 21 (trisomy 21), face a\u2026","rel":"","context":"In "Blog"","block_context":{"text":"Blog","link":"https:\/\/www.globaldownsyndrome.org\/sw\/category\/blog\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/www.globaldownsyndrome.org\/wp-content\/uploads\/2023\/07\/DSW-Article.png?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/www.globaldownsyndrome.org\/wp-content\/uploads\/2023\/07\/DSW-Article.png?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/www.globaldownsyndrome.org\/wp-content\/uploads\/2023\/07\/DSW-Article.png?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/www.globaldownsyndrome.org\/wp-content\/uploads\/2023\/07\/DSW-Article.png?resize=700%2C400&ssl=1 2x"},"classes":[]}],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.globaldownsyndrome.org\/sw\/wp-json\/wp\/v2\/posts\/152841","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.globaldownsyndrome.org\/sw\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.globaldownsyndrome.org\/sw\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.globaldownsyndrome.org\/sw\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.globaldownsyndrome.org\/sw\/wp-json\/wp\/v2\/comments?post=152841"}],"version-history":[{"count":0,"href":"https:\/\/www.globaldownsyndrome.org\/sw\/wp-json\/wp\/v2\/posts\/152841\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.globaldownsyndrome.org\/sw\/wp-json\/wp\/v2\/media\/152842"}],"wp:attachment":[{"href":"https:\/\/www.globaldownsyndrome.org\/sw\/wp-json\/wp\/v2\/media?parent=152841"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.globaldownsyndrome.org\/sw\/wp-json\/wp\/v2\/categories?post=152841"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.globaldownsyndrome.org\/sw\/wp-json\/wp\/v2\/tags?post=152841"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}