Two-time Academy Award Nominee Jeremy Renner is BACK to headline GLOBAL’s star-studded Be Beautiful Be Yourself Fashion Show!

“I’m honored to be invited back to GLOBAL’s amazing event and to hang out with some of the coolest people who happen to have Down syndrome,” Jeremy shared. “I’m excited to give back in a meaningful way, to help raise funds for research that will lead to healthier, longer lives. It’s going to be a great night, and I hope we can break some records!”

Experience the magic on Saturday, October 18, 2025.

We are grateful to Alex and Ashley Singleton who are taking a stand and support GLOBAL in condemning the use of the R-word. There has been a dramatic increase in the use of the word on socials. The use is dehumanizing, dangerous, and cowardly.

Twenty-one of the most beautiful models from around the country and 11 different states will rock the runway at the largest Down syndrome fundraiser in the world! Check out the model’s amazing bio and consider sponsoring a model today. 

Updated Down Syndrome Medical Centers: We are proud to share this GLOBAL resource that includes NEW medical centers in CT, MS, and DC! We contacted each center and updated info on insurance, ages served, days & hours of clinic, and services provided.

Thanks to Drs. Michael S. Rafii & Jonathan Santoro for highlighting GLOBAL’s gov’t advocacy & establishment of the NIH INCLUDE Project. Read their important article on Alzheimer’s & DS in The Lancet – click “Get Access” and create a free account!