Linda Crnic Institute
for Down Syndrome
The Global Down Syndrome Foundation provides fundraising, education, awareness and government advocacy for the Linda Crnic Institute for Down Syndrome.
Established in 2008, the Linda Crnic Institute for Down Syndrome is the first academic home for Down syndrome research in the United States. The mission of the Crnic Institute is to significantly improve the lives of people with Down syndrome by eradicating the medical and cognitive ill effects associated with the condition.
Learn more about the Linda Crnic Institute.
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Keep up with government advocacy, medical and research news, upcoming programs, events and educational conferences.
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Discover moreJoin Global in Washington DC as we honor advocates and celebrate people with Down syndrome
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Discover moreCelebrate World Down Syndrome Day on 3/21 with Global's I ♥ YOU Dance Party!
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Discover moreMeet Quincy Jones Advocacy Award winner Tim Harris, who just appeared on "The View"
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Discover moreDr. Huntington Potter is leading the way in Alzheimer's disease-Down syndrome research
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Discover moreCrnic Institute set to award another $1 million in grants for Down syndrome research
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Discover moreJoin Global spokesman John C. McGinley in the fight to eliminate the use of words that hurt
Blog
In recognition of Febuary as American Heart Month, the Global Down Syndrome Foundation held a Question & Answer session with Dr. Francis Hickey, the Medical Director at the Anna and John J. Sie Center for Down Syndrome at Children’s Hospital Colorado. Dr. Hickey has received one of the inaugural Crnic Institute Grand Challenge Grants, to study the pharmacokinetics of morphine in post-operative cardiac patients with Down syndrome.
Medical professionals, self-advocates and parents of people with Down syndrome will have access to 14 innovative educational programs across the U.S. and Puerto Rico through $155,000 in Global Down Syndrome Educational Grants.
This year’s grants, varying from $6,000 to $10,000 and benefiting eight local Down syndrome organizations, are being announced on International Day of Persons with Disabilities.
In recognition of November as National Alzheimer’s Disease Awareness Month, the Global Down Syndrome Foundation held a Q&A with Dr. Matt Kennedy, who has received one of the inaugural Crnic Institute Grand Challenge Grants. Kennedy received the award for his research into commonalities between Alzheimer’s disease and Down syndrome, specifically the loss of synapses in the brain and the increased production of a toxic peptide called beta-amyloid.
The Global Down Syndrome Foundation has launched a comprehensive directory of Down syndrome medical care centers in the U.S. This important directory provides people with Down syndrome and their families with accurate and useful information about medical care centers near them, by state. The directory includes 66 centers, many of which have filled in all the directory data.
Linda Crnic Institute for Down Syndrome
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 V. Balasubramaniam, M.D.
Sleep apnea and Down syndrome Examine the effect of sleep apnea on vascular stem cells in people with Down syndrome |
 Christopher Link, Ph.D.
Genetic understanding of Down syndrome Determine which genes have altered expression due to Trisomy 21 |
 James DeGregori, Ph.D.
Leukemia and Down syndrome Study increase in leukemia incidence and other problems with blood cell production, including reduced immunity |
 Karl Pfenninger, M.D.
Cognition and Down syndrome Study causes of intellectual disability associated with Down syndrome, specifically the APP protein |
 Robin Dowell, Ph.D.
Genetic understanding of Down syndrome Understand how Trisomy 21 affects the behavior of key proteins involved in regulating expression |
 Tamim H. Shaikh, Ph.D.
Autism and Down syndrome Research genetic modifiers of autism spectrum disorders in patients with Down syndrome |
 Joaquin Espinosa, Ph.D.
Genetic understanding of Down syndrome Identify genes whose function is essential in trisomic cells yet dispensable in cells with only two copies of chromosome 21 |
 Richard Spritz, M.D.
Autoimmune disorders and Down syndrome Analyze autoimmunity genetics in Down syndrome — thyroid disease, celiac disease, type 1 diabetes and rheumatoid arthritis |
 Fran Hickey, M.D.
Anesthesia and Down syndrome Provide information to improve management of post-operative pain and sedation in children with Down syndrome |
 Ding Xue, Ph.D.
Alzheimer’s disease and Down syndrome Study the roles of presenilin and ubiquilin in developing treatments for Alzheimer’s disease in patients with Down syndrome |
 Kevin Jones, Ph.D.
Gene regulation and Down syndrome Test whether increasing the abundance of the BDNF protein can prevent Down syndrome pathology in a mouse model |
 Michael Yeager, Ph.D.
Autoimmune disorders and Down syndrome Understand immune system disturbances in individuals with Down syndrome and drive development of newer therapies |
 Matthew Kennedy, Ph.D.
Alzheimer’s disease and Down syndrome Investigate how increased beta-amyloid production causes synapse loss in hope of finding targets for future therapies |
 Rui Yi, Ph.D.
Genetic understanding of Down syndrome Determine the effect of gene dosage imbalance on activity in trisomic embryonic stem cells |
Meet the full Supergroup |
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