Linda Crnic Institute
for Down Syndrome

The Global Down Syndrome Foundation provides fundraising, education, awareness and government advocacy for the Linda Crnic Institute for Down Syndrome.

Established in 2008, the Linda Crnic Institute for Down Syndrome is the first academic home for Down syndrome research in the United States. The mission of the Crnic Institute is to significantly improve the lives of people with Down syndrome by eradicating the medical and cognitive ill effects associated with the condition.

Learn more about the Linda Crnic Institute.
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Keep up with research news, upcoming programs, events and educational conferences.

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Make sure your local Representatives are on the Congressional Down Syndrome Caucus.

  • Support Dare to Ride Team and Life-Changing Medical Care at Sie Center for Down Syndrome
    Discover more

    Support Dare to Ride Team and Life-Changing
    Medical Care at Sie Center for Down Syndrome

  • Award-winning Actor Will Attend Global's Be Beautiful Be Yourself Fashion Show on October 24
    Discover more

    Award-winning Actor Will Attend Global's
    Be Beautiful Be Yourself Fashion Show on October 24

  • Check Out the Latest Issue of "Down Syndrome World" Featuring Lauren Potter & Jane Lynch
    Discover more

    Check Out the Latest Issue of "Down Syndrome World" Featuring Lauren Potter & Jane Lynch

  • Donate Today! Support our Dare to Ride team and the Sie Center for Down Syndrome
    Discover more

    Donate Today! Support our Dare to Ride team
    and the Sie Center for Down Syndrome

  • Meet 2015 Global Down Syndrome Foundation Ambassador Clarissa Joann Capuano
    Discover more

    Meet 2015 Global Down Syndrome Foundation
    Ambassador Clarissa Joann Capuano

  • Learn More About Down Syndrome with Global's Facts & Frequently Asked Questions
    Discover more

    Learn More About Down Syndrome with Global's
    Facts & Frequently Asked Questions

Blog

Dare to Ride Team
Dare to Ride Team Supports the Sie Center
The July bike tour through the beautiful Rockies helps fund life-changing medical care for children and young adults with Down syndrome. The Dare to Ride Team is organized by Global to support the Anna and John J. Sie Center For Down Syndrome at Children’s Hospital Colorado, one of the largest pediatric medical care centers for Down syndrome in the world.

July 18-20, 2015
Copper Mountain, Colorado

 
 

People with Down's Syndrome Sitting Around Table --- Image by © Markus Moellenberg/Corbis
Global’s Survey to Benefit Adults with DS
The Global Down Syndrome Foundation is planning to open their first Adult Down Syndrome Medical Center, Summer of 2016, which will be located in Colorado. ‎This new Center will complement Global’s existing affiliates — the Crnic Institute and the Sie Center for Down Syndrome — in providing a spectrum of research and medical care to the Down syndrome community.

 
 

Dare to Play Football“Dare to” Football & Cheer Camps Inspire Crowds
Join the Global Down Syndrome Foundation on Game Day and celebrate amazing self-advocates in Global’s Dare to Play Football Camp with Ed McCaffrey and Dare to Cheer Camp with the Denver Broncos Cheerleaders!

Saturday, June 20, 2015, 10:30am – 2:00pm
Valor Christian High School
3775 Grace Blvd., Highlands Ranch, CO 80126

 
 

Washington Post ArticleWA Post Profiles Global’s DS-Alzheimer’s Work
The Global Down Syndrome Foundation, the Linda Crnic Institute for Down Syndrome and the national Alzheimer’s Association co-sponsored a seminal workshop calling attention to the connection between Down syndrome and Alzheimer’s disease. This important workshop was profiled in The Washington Post.

 
 
 
 

Young Munich Couple Visits Denver and Global
Aurel is a beautiful boy who happens to have Down syndrome. His parents, Aina Dressler and Robert Conle, share their personal story of hope, love and family.

 
 
 
 
 

Global Updates Congress on Latest Advances
Co-organized by the Global Down Syndrome Foundation, the Congressional Down Syndrome Caucus Briefing was held at the U.S. Capitol on April 22. The briefing, entitled “21st Century Advances in Down Syndrome Research Advocacy,” attracted over 40 people, including Members of Congress, congressional staff, self-advocates, family members and Down syndrome community leaders.

 
 

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Linda Crnic Institute for Down Syndrome
The Leader in scientific research benefiting people with Down syndrome

Meet the Crnic Institute Supergroup 2013 Grant Recipients

V. Balasubramaniam, M.D.
Sleep apnea and Down syndrome
Examine the effect of sleep apnea on vascular stem cells in people with Down syndrome
Christopher Link, Ph.D.
Genetic understanding of Down syndrome
Determine which genes have altered expression due to Trisomy 21
James DeGregori, Ph.D.
Leukemia and Down syndrome
Study increase in leukemia incidence and other problems with blood cell production, including reduced immunity
Karl Pfenninger, M.D.
Cognition and Down syndrome
Study causes of intellectual disability associated with Down syndrome, specifically the APP protein
Robin Dowell, Ph.D.
Genetic understanding of Down syndrome
Understand how Trisomy 21 affects the behavior of key proteins involved in regulating expression
Tamim H. Shaikh, Ph.D.
Autism and Down syndrome
Research genetic modifiers of autism spectrum disorders in patients with Down syndrome
Joaquin Espinosa, Ph.D.
Genetic understanding of Down syndrome
Identify genes whose function is essential in trisomic cells yet dispensable in cells with only two copies of chromosome 21
Richard Spritz, M.D.
Autoimmune disorders and Down syndrome
Analyze autoimmunity genetics in Down syndrome — thyroid disease, celiac disease, type 1 diabetes and rheumatoid arthritis
Fran Hickey, M.D.
Anesthesia and Down syndrome
Provide information to improve management of post-operative pain and sedation in children with Down syndrome
Ding Xue, Ph.D.
Alzheimer’s disease and Down syndrome
Study the roles of presenilin and ubiquilin in developing treatments for Alzheimer’s disease in patients with Down syndrome
Kevin Jones, Ph.D.
Gene regulation and Down syndrome
Test whether increasing the abundance of the BDNF protein can prevent Down syndrome pathology in a mouse model
Michael Yeager, Ph.D.
Autoimmune disorders and Down syndrome
Understand immune system disturbances in individuals with Down syndrome and drive development of newer therapies
Matthew Kennedy, Ph.D.
Alzheimer’s disease and Down syndrome
Investigate how increased beta-amyloid production causes synapse loss in hope of finding targets for future therapies
Rui Yi, Ph.D.
Genetic understanding of Down syndrome
Determine the effect of gene dosage imbalance on activity in trisomic embryonic stem cells

Meet the full Supergroup