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Make sure your local Representatives are on the Congressional Down Syndrome Caucus.

  • Apply for Global Down Syndrome Foundation Educational Grants
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    Apply for Global Down Syndrome Foundation Educational Grants

  • Sie Center’s Impact Grows with 3 New Clinics
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    Sie Center’s Impact Grows with 3 New Clinics

  • Nebraska Welcomes Global, Supports Fashion Show
    Learn More

    Nebraska Welcomes Global, Supports Fashion Show


Marwan Sabbagh, M.D.$1 Million in Grants for Alzheimer Disease-Down Syndrome Research


Joan MedlenNutrition Expert Keynotes Global’s Education Series

Joan Medlen is a registered dietitian and DS expert who has published 2 popular books promoting healthy lifestyles for people who are differently-abled.

Global Down Syndrome Foundation
Fall 2015 Education Series
November 20-21, 2015

Hunt and Long
Longitudinal AD and DS Study at Crnic Institute
Help further research by participating in a study overseen by Dr. Huntington Potter and the Rocky Mountain Alzheimer’s Disease Center
Global Grant Funds Employment Initiative
Global celebrates Down Syndrome Awareness Month by announcing a new grant program that aims to increase jobs for self-advocates.

carlos-and-wifeCarlos González Goes to Bat for Global Down Syndrome Foundation
Rockies star player will strut his stuff on the runway to support Down syndrome research and medical care at Global’s Be Beautiful Be Yourself Fashion Show on Saturday, October 24, 2015
miss co dr ozMiss Colorado Supports Global and Appears on Dr. Oz
Miss Colorado will escort Global’s models with Down syndrome at the October 24 Be Beautiful Be Yourself Fashion Show. She responded to criticism and praise after advocating for nurses during her monologue for the talent portion of the Miss America pageant. Watch her TV appearances and viral monologue.


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Linda Crnic Institute for Down Syndrome
The leader in scientific research benefiting people with Down syndrome

Meet the Crnic Institute Supergroup 2016 Grant Recipients

Brianne Bettcher, PhD

Alzheimer’s and Down syndrome
investigate the correlation between biomarkers of inflammation, brain structure, and neuropsychological functioning

Christopher Link, PhD

Genetic understanding of Down syndrome
Determine which genes have altered expression due to Trisomy 21

Ganna Bilousova, PhD

Stem cells and Down syndrome
Exploring Endothelial Progenitor Cell Defects in Down Syndrome

Changwei Liu, PhD

Protein expression & Down syndrome
Study the effect of USP16 overexpression on a large number of other cellular proteins to determine whether USP16 may be key to many phenotypes

Zhe Chen, PhD

Neurology & Down syndrome
Study how an extra copy of chromosome 21 affects axon guidance in the brain

Ken Maclean, PhD

Cognition & Down syndrome
Test a highly specific inhibitor of a key protein active in the Unfolded Protein Response as a potential therapeutic target for cognitive deficits

Mark Dell’Acqua,

Alzheimer’s disease & Down syndrome
Study the role of calcium signaling in inhibition of synapse formation by A-beta plaque in Down syndrome

Steven Maier, PhD

Cognition & Down syndrome
Understand the contribution of inflammation in the brain to cognitive deficits of Down syndrome

James DeGregori, PhD

Leukemia & Down syndrome
Study increase in leukemia incidence and other problems with blood cell production, including reduced immunity

William Old, PhD

Protein expression & Down syndrome
Study genes with altered protein expression to develop new therapeutic strategies to alleviate issues with neurodevelopment and neurodegenerative pathologies

and trisomic 21 cerebral organoids

Robin Dowell, PhD

Genetic understanding of Down syndrome
Understand how an extra copy of chromosome 21 affects the behavior of key proteins involved in regulating expression

Bradley Olwin, PhD

Muscle development & Down syndrome
Test the idea that muscle weakness in Down syndrome is due to failure of muscle stem cells to function properly

Joaquín Espinosa, PhD

Genetic understanding of Down syndrome
Identify genes whose function is essential in trisomic cells yet dispensable in cells with only two copies of chromosome 21

Chad Pearson, PhD

Cell signaling in Down syndrome
A new ciliary basis for understanding Down
syndrome phenotypes

Kirk Hansen, PhD

Proteomics of Down syndrome
Metabolic Alterations of Trisome 21

Anne-Laure Perraud, PhD

Immune dysfunction & Down syndrome
Determine the role of a chromosome 21 protein that forms an ion channel in innate immune dysfunction in Down syndrome

Francis J. Hickey, MD

Anesthesia & Down syndrome
Provide information to improve management of post-operative pain and sedation in children with Down syndrome

Chris Porter, PhD

Immune system and Down syndrome
define the impact of trisomy 21 on immune cells in the human body

Charles A. Hoeffer, PhD

Alzheimer’s disease & Down syndrome
Test the idea that overexpression of a key gene on chromosome 21 promotes the development of Alzheimer’s disease-related neuropathology

Tamim H. Shaikh, PhD

Autism & Down syndrome
Research genetic modifiers of autism spectrum disorders in patients with Down syndrome

Aaron Johnson, PhD

Genetic understanding of Down syndrome
Reconstitute chromosome 21 in the test tube to understand how it can be turned off by an RNA molecule

Richard Spritz, MD

Autoimmune disorders & Down syndrome
Analyze genetics of autoimmunity in Down syndrome — thyroid disease, celiac disease, type 1 diabetes and rheumatoid arthritis

Kevin Jones, PhD

Gene regulation & Down syndrome
Test whether increasing the abundance of the BDNF protein can prevent Down syndrome pathology in a mouse model

Jerry Stitzel, PhD

Cognition & Down syndrome
Study gene expression changes specifically in a key group of neurons to improve our understanding of the molecular pathology of neuron loss in Down syndrome

Harald Junge, PhD

Optic development & Down syndrome
Determine the effects of Trisomy 21 on optic nerve development and function

Kelly Sullivan, PhD

Interferon Activity & Down syndrome
Defining the impact of modulating Interferon activity on cells from individuals with trisomy 21.

Matthew Kennedy, PhD

Alzheimer’s disease & Down syndrome
Investigate how increased beta-amyloid production causes synapse loss in hope of finding targets for future therapies

Ding Xue, PhD

Alzheimer’s disease & Down syndrome
Study the roles of presenilin and ubiquilin in developing treatments for Alzheimer’s disease in patients with Down syndrome

Michael Klymkowsky, PhD

Neurodevelopment in Down syndrome
Inductive signaling in human iPSC-derived euploid and trisomic 21 cerebral organoids

Michael Yeager, PhD

Autoimmune disorders & Down syndrome
Understand immune system disturbances in individuals with Down syndrome and drive development of newer therapies

Rui Yi, PhD

Genetic understanding of Down syndrome
Determine the effect of gene dosage imbalance on activity in trisomic embryonic stem cells