Linda Crnic Institute
for Down Syndrome

The Global Down Syndrome Foundation provides fundraising, education, awareness and government advocacy for the Linda Crnic Institute for Down Syndrome.

Established in 2008, the Linda Crnic Institute for Down Syndrome is the first academic home for Down syndrome research in the United States. The mission of the Crnic Institute is to significantly improve the lives of people with Down syndrome by eradicating the medical and cognitive ill effects associated with the condition.

Learn more about the Linda Crnic Institute.
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Make sure your local Representatives are on the Congressional Down Syndrome Caucus.

  • Winter 2015 Down Syndrome World
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    Check Out the New Issue of "Down Syndrome World" Featuring John C. McGinley and His Son Max

  • Register Now for 2015 Be Beautiful Be Yourself Fashion Show Model Auditions on May 13th
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    Register Now for 2015 Be Beautiful Be Yourself Fashion Show Model Auditions on May 13th

  • Crnic Institute Announces $1 Million in Grants for Down Syndrome Research
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    Crnic Institute Announces $1 Million in Grants for Down Syndrome Research

  • Global Down Syndrome Foundation Educational Grants
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    Applications Now Available for 2015 Global Down Syndrome Foundation Educational Grants

  • Jane Lynch
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    Jane Lynch Hosts Global Down Syndrome Foundation & Self-Advocates During "See Jane Sing" Tour

  • Global Down Syndrome Foundation helps establish Trisomy 21 Research Society
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    Global Helps Establish Trisomy 21 Research Society; First Conference To Be in Paris in June


Empire State Building, Denver’s Daniels and Fisher Tower to light up for World Down Syndrome Day
The Empire State Building in New York City and the historic Daniels & Fisher Tower in downtown Denver will light up blue and yellow in honor of World Down Syndrome Day on the night of Saturday, March 21, 2015. The Empire State Building image is a registered trademark of ESRT Empire State Building, L.L.C. and is used with permission.


Anna Sie and Sophia
Global Down Syndrome Foundation honors Anna Sie as Community Leader
The Global Down Syndrome Foundation is proud to announce longtime supporter Anna Sie will receive the Global Community Leadership Award at the World Down Syndrome Day celebration at Children’s Hospital Colorado on Friday, March 20, 2015. The celebration is co-hosted by Global and the Sie Center for Down Syndrome – one of the largest pediatric medical care centers dedicated to children with Down syndrome.


Dr. Karl Pfenninger
Dr. Karl Pfenninger leaves legacy of science
Recently, we lost Dr. Karl H. Pfenninger to his battle with brain cancer. Dr. Pfenninger was one of four principal investigators at the Linda Crnic Institute for Down Syndrome and a professor of pediatrics at the University of Colorado School of Medicine. He was also director of the Colorado Intellectual and Developmental Disabilities Research Center (IDDRC), a position formerly held by Linda Crnic, the namesake of the Crnic Institute.


Dr. Francis Hickey
ENT conference has first Down syndrome panel
The Sie Center’s Dr. Francis Hickey and Global’s Michelle Sie Whitten present at the national otolaryngology conference in Vail. Since the late 1960s, the University of Colorado School of Medicine’s Department of Otolaryngology has hosted the “Ultimate Colorado Midwinter Meeting,” a national Otolaryngology (Ears, Nose, Throat, or “ENT”) conference in Vail. This year, the conference organized its first Down syndrome-specific panel of experts.


Baby Leo
Armenian story shows we must stay vigilant
In the pursuit of human rights for people with Down syndrome, even where there are anti-discrimination laws, they aren’t always followed. In the recent case of “Baby Leo,” the birth of one child with Down syndrome in Armenia has sparked a worldwide discussion about the rights of the differently-abled, government policies regarding communication with new parents, and the need for improved education and awareness.


Jamie Foxx and DeOndra Dixon
Jamie Foxx, on life with his little sister, DeOndra Dixon
Oscar and Grammy winner Jamie Foxx is a triple threat as an actor, musician and comedian, and he’s also a great big brother to self-advocate DeOndra Dixon. Foxx, who is a Global Down Syndrome Foundation Quincy Jones Exceptional Advocacy Award recipient, recently spoke with Down Syndrome World magazine about DeOndra and how she’s earned her own place in the spotlight.


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Linda Crnic Institute for Down Syndrome
The Leader in scientific research benefiting people with Down syndrome

Meet the Crnic Institute Supergroup 2013 Grant Recipients

V. Balasubramaniam, M.D.
Sleep apnea and Down syndrome
Examine the effect of sleep apnea on vascular stem cells in people with Down syndrome
Christopher Link, Ph.D.
Genetic understanding of Down syndrome
Determine which genes have altered expression due to Trisomy 21
James DeGregori, Ph.D.
Leukemia and Down syndrome
Study increase in leukemia incidence and other problems with blood cell production, including reduced immunity
Karl Pfenninger, M.D.
Cognition and Down syndrome
Study causes of intellectual disability associated with Down syndrome, specifically the APP protein
Robin Dowell, Ph.D.
Genetic understanding of Down syndrome
Understand how Trisomy 21 affects the behavior of key proteins involved in regulating expression
Tamim H. Shaikh, Ph.D.
Autism and Down syndrome
Research genetic modifiers of autism spectrum disorders in patients with Down syndrome
Joaquin Espinosa, Ph.D.
Genetic understanding of Down syndrome
Identify genes whose function is essential in trisomic cells yet dispensable in cells with only two copies of chromosome 21
Richard Spritz, M.D.
Autoimmune disorders and Down syndrome
Analyze autoimmunity genetics in Down syndrome — thyroid disease, celiac disease, type 1 diabetes and rheumatoid arthritis
Fran Hickey, M.D.
Anesthesia and Down syndrome
Provide information to improve management of post-operative pain and sedation in children with Down syndrome
Ding Xue, Ph.D.
Alzheimer’s disease and Down syndrome
Study the roles of presenilin and ubiquilin in developing treatments for Alzheimer’s disease in patients with Down syndrome
Kevin Jones, Ph.D.
Gene regulation and Down syndrome
Test whether increasing the abundance of the BDNF protein can prevent Down syndrome pathology in a mouse model
Michael Yeager, Ph.D.
Autoimmune disorders and Down syndrome
Understand immune system disturbances in individuals with Down syndrome and drive development of newer therapies
Matthew Kennedy, Ph.D.
Alzheimer’s disease and Down syndrome
Investigate how increased beta-amyloid production causes synapse loss in hope of finding targets for future therapies
Rui Yi, Ph.D.
Genetic understanding of Down syndrome
Determine the effect of gene dosage imbalance on activity in trisomic embryonic stem cells

Meet the full Supergroup