Linda Crnic Institute
for Down Syndrome

The Global Down Syndrome Foundation provides fundraising, education, awareness and government advocacy for the Linda Crnic Institute for Down Syndrome.

Established in 2008, the Linda Crnic Institute for Down Syndrome is the first academic home for Down syndrome research in the United States. The mission of the Crnic Institute is to significantly improve the lives of people with Down syndrome by eradicating the medical and cognitive ill effects associated with the condition.

Learn more about the Linda Crnic Institute.
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Keep up with research news, upcoming programs, events and educational conferences.

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Make sure your local Representatives are on the Congressional Down Syndrome Caucus.

  • Renowned Musician and Self-Advocate Sujeet Desai Visits Denver to tour Crnic Institute and Sie Center
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    Renowned Musician and Self-Advocate Sujeet Desai Visits Denver to tour Crnic Institute and Sie Center

  • Check Out the Latest Issue of "Down Syndrome World" Featuring Beverly Johnson and Niece Natalie Fuller
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    Check Out the Latest Issue of "Down Syndrome World" Featuring Beverly Johnson and Niece Natalie Fuller

  • Registration is Now Open - Dare to Play Soccer with Regis Men’s Soccer and the Colorado Rapids
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    Registration is Now Open - Dare to Play Soccer with Regis Men’s Soccer and the Colorado Rapids

  • Global's Team Raises $50,000 for the Sie Center to Provide High Quality Care from Prenatal to Age 21
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    Global's Team Raises $50,000 for the Sie Center to Provide High Quality Care from Prenatal to Age 21

  • Purchase your table or tickets for the Be Beautiful Be Yourself Fashion Show
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    Purchase your table or tickets for the Be Beautiful Be Yourself Fashion Show

  • Learn More About Down Syndrome with Global's Facts & Frequently Asked Questions
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    Learn More About Down Syndrome with Global's
    Facts & Frequently Asked Questions

Blog

RoundtablePanelAlzheimer’s-DS Seminal Conference in Arizona
A packed house heard from leading scientists and clinicians at Global’s Research and Medical Care Roundtable: “Alzheimer’s Disease and Down Syndrome – What Parents and Caregivers Should Know.” Global’s Roundtable attracted world-renowned Down syndrome and Alzheimer’s disease experts to the NDSC Annual Convention in Phoenix, Arizona, on June 25.

 
 

FOX Broadcasting Company, Twentieth Century FOX Television And FX Post Emmy PartyGlobal to Honor Actress and Model Jamie Brewer
Jamie Brewer, the “American Horror Story” star, will receive the 2015 Quincy Jones Exceptional Advocacy Award at Global’s Be Beautiful Be Yourself Fashion Show on October 24. Brewer made headlines earlier this year when she rocked the runway at New York Fashion Week as the first model with Down syndrome to walk.

 
 
 
 
 

Megan and DevonFirst Lady Celebrates Global Self-Advocates in DC
College-bound Devon Adelman and Megan Bomgaars represent Global at First Lady Michelle Obama’s 2015 “Beating the Odds” summit at the White House. The event is part of the First Lady’s Reach Higher Campaign, which celebrates students who have overcome the “odds” to attend college.

 
 
 
 

Educational Grants
Global Grants Fund 31 Educational Programs
The Global Down Syndrome Foundation Educational Grants have provided over $300,000 to local Down syndrome organizations from around the United States funding 31 innovative educational programs to medical professionals, self-advocates and parents of people with Down syndrome.

 
 
 

Hollywood Ball
Generous Grant Funds Global’s Hollywood Ball
The Salah Foundation helps fund adult education programs including the Be Beautiful Be Yourself Hollywood Ball. The fourth annual Be Beautiful Be Yourself Hollywood Ball “Gold & Glam” was held on Friday, June 12, 2015 in the elegant Grand Ballroom at the Four Seasons Hotel in downtown Denver. Over 130 adults with Down syndrome and guests attended.

 
 
 
 
 


Global’s Alzheimer’s Initiative Receives $500,000
Colorado Governor John Hickenlooper and the state legislature allocate $500,000 for the Rocky Mountain Alzheimer’s Disease Center. The state has now invested $750,000 to support the first Alzheimer’s disease research and clinical care center in Colorado and the first in the U.S. with a specific focus on Down syndrome.

 

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Linda Crnic Institute for Down Syndrome
The Leader in scientific research benefiting people with Down syndrome

Meet the Crnic Institute Supergroup 2013 Grant Recipients

V. Balasubramaniam, M.D.
Sleep apnea and Down syndrome
Examine the effect of sleep apnea on vascular stem cells in people with Down syndrome
Christopher Link, Ph.D.
Genetic understanding of Down syndrome
Determine which genes have altered expression due to Trisomy 21
James DeGregori, Ph.D.
Leukemia and Down syndrome
Study increase in leukemia incidence and other problems with blood cell production, including reduced immunity
Karl Pfenninger, M.D.
Cognition and Down syndrome
Study causes of intellectual disability associated with Down syndrome, specifically the APP protein
Robin Dowell, Ph.D.
Genetic understanding of Down syndrome
Understand how Trisomy 21 affects the behavior of key proteins involved in regulating expression
Tamim H. Shaikh, Ph.D.
Autism and Down syndrome
Research genetic modifiers of autism spectrum disorders in patients with Down syndrome
Joaquin Espinosa, Ph.D.
Genetic understanding of Down syndrome
Identify genes whose function is essential in trisomic cells yet dispensable in cells with only two copies of chromosome 21
Richard Spritz, M.D.
Autoimmune disorders and Down syndrome
Analyze autoimmunity genetics in Down syndrome — thyroid disease, celiac disease, type 1 diabetes and rheumatoid arthritis
Fran Hickey, M.D.
Anesthesia and Down syndrome
Provide information to improve management of post-operative pain and sedation in children with Down syndrome
Ding Xue, Ph.D.
Alzheimer’s disease and Down syndrome
Study the roles of presenilin and ubiquilin in developing treatments for Alzheimer’s disease in patients with Down syndrome
Kevin Jones, Ph.D.
Gene regulation and Down syndrome
Test whether increasing the abundance of the BDNF protein can prevent Down syndrome pathology in a mouse model
Michael Yeager, Ph.D.
Autoimmune disorders and Down syndrome
Understand immune system disturbances in individuals with Down syndrome and drive development of newer therapies
Matthew Kennedy, Ph.D.
Alzheimer’s disease and Down syndrome
Investigate how increased beta-amyloid production causes synapse loss in hope of finding targets for future therapies
Rui Yi, Ph.D.
Genetic understanding of Down syndrome
Determine the effect of gene dosage imbalance on activity in trisomic embryonic stem cells

Meet the full Supergroup