Linda Crnic Institute
for Down Syndrome

The Global Down Syndrome Foundation provides fundraising, education, awareness and government advocacy for the Linda Crnic Institute for Down Syndrome.

Established in 2008, the Linda Crnic Institute for Down Syndrome is the first academic home for Down syndrome research in the United States. The mission of the Crnic Institute is to significantly improve the lives of people with Down syndrome by eradicating the medical and cognitive ill effects associated with the condition.

Learn more about the Linda Crnic Institute.
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Make sure your local Representatives are on the Congressional Down Syndrome Caucus.

  • Jamie Foxx and DeOndra Dixon help launch Down Syndrome World magazine
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    Jamie Foxx and DeOndra Dixon Help Launch
    "Down Syndrome World" Quarterly Magazine

  • Register Now for the 2015 Be Beautiful Be Yourself DC Gala Model Auditions
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    Register Now for the 2015 Be Beautiful Be Yourself DC Gala Model Auditions

  • Alec Baldwin at the Be Beautiful Be Yourself Fashion Show
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    Be Beautiful Be Yourself Fashion Show Breaks Record by Raising $1.9 Million

  • Helen Hunt and Brad Hennefer
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    Celebrities Shine a National Spotlight
    on Global Down Syndrome Foundation

  • John C. McGinley and Laura Dern
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    Q&A: Catching Up with Award-Winning Actor John C. McGinley

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    Be Beautiful Be Yourself Dancers to Perform in Colorado Ballet's "Nutcracker"

Blog

Salah Foundation
Salah Foundation Grant Provides for Programs for Adults with Down Syndrome
A generous matching grant from the Salah Foundation will provide $200,000 to underwrite Global’s important new initiative for adults with Down syndrome. The $200,000 in total matched funds allows Global to work with world-class researchers to create evidence-based educational programs for adults with Down syndrome in the areas of safety, health, nutrition, and communication & speech. Global intends to share the results of the research with the greater community in the hopes that programming that is proven will be replicated.

 

Amanda Seligman and Shima
Sie Center’s New Speech Language Pathologist Amanda Seligman
The Sie Center for Down Syndrome’s new speech language pathologist Amanda Seligman shares important speech development tips for parents of children with Down syndrome. The Sie Center for Down Syndrome at Children’s Hospital Colorado is one of the largest multi-disciplinary teams in the world providing medical care and research for children with Down syndrome.

 
 

DS-Connect registry
NIH’s DS-Connect Registry Unites Down Syndrome Community
DS-Connect promises a path to research breakthroughs. If you are a parent or a guardian, help your loved one with Down syndrome and sign up now. DS-Connect™: The Down Syndrome Registry is a vital new resource for people with Down syndrome, giving thousands of individuals access to a community of researchers working to improve their health and well-being.

 
 
 
 
 
 
 

Bill and Leslie Vollbracht
For Vollbrachts, Support for Global is a Family Affair
For Bill and Leslie Vollbracht, supporting the Global Down Syndrome Foundation is a family investment in their granddaughter and others who have Down syndrome. Seasoned entrepreneurs, the Vollbrachts are betting on Global’s research, medical care and outreach. They recently sat down with Global to talk about Colorado, family and why support for Down syndrome medical care and research is so important.

 
 
 
 
 
 

$5 Million Dollar NIH / NIA Alzheimer’s and Down Syndrome Grant Announced!
The Global Down Syndrome Foundation is pleased to announce a new grant opportunity from the National Institute of Aging. The 2 grants totaling $5 million dollars will be awarded in late 2015. The goal of this funding opportunity is to enable the longitudinal progression of Alzheimer’s disease in adults with Down Syndrome using clinical, cognitive, imaging, genetic and biochemical biomarkers.

 
 
 
 
 
 
 

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Linda Crnic Institute for Down Syndrome
The Leader in scientific research benefiting people with Down syndrome

Meet the Crnic Institute Supergroup 2013 Grant Recipients

V. Balasubramaniam, M.D.
Sleep apnea and Down syndrome
Examine the effect of sleep apnea on vascular stem cells in people with Down syndrome
Christopher Link, Ph.D.
Genetic understanding of Down syndrome
Determine which genes have altered expression due to Trisomy 21
James DeGregori, Ph.D.
Leukemia and Down syndrome
Study increase in leukemia incidence and other problems with blood cell production, including reduced immunity
Karl Pfenninger, M.D.
Cognition and Down syndrome
Study causes of intellectual disability associated with Down syndrome, specifically the APP protein
Robin Dowell, Ph.D.
Genetic understanding of Down syndrome
Understand how Trisomy 21 affects the behavior of key proteins involved in regulating expression
Tamim H. Shaikh, Ph.D.
Autism and Down syndrome
Research genetic modifiers of autism spectrum disorders in patients with Down syndrome
Joaquin Espinosa, Ph.D.
Genetic understanding of Down syndrome
Identify genes whose function is essential in trisomic cells yet dispensable in cells with only two copies of chromosome 21
Richard Spritz, M.D.
Autoimmune disorders and Down syndrome
Analyze autoimmunity genetics in Down syndrome — thyroid disease, celiac disease, type 1 diabetes and rheumatoid arthritis
Fran Hickey, M.D.
Anesthesia and Down syndrome
Provide information to improve management of post-operative pain and sedation in children with Down syndrome
Ding Xue, Ph.D.
Alzheimer’s disease and Down syndrome
Study the roles of presenilin and ubiquilin in developing treatments for Alzheimer’s disease in patients with Down syndrome
Kevin Jones, Ph.D.
Gene regulation and Down syndrome
Test whether increasing the abundance of the BDNF protein can prevent Down syndrome pathology in a mouse model
Michael Yeager, Ph.D.
Autoimmune disorders and Down syndrome
Understand immune system disturbances in individuals with Down syndrome and drive development of newer therapies
Matthew Kennedy, Ph.D.
Alzheimer’s disease and Down syndrome
Investigate how increased beta-amyloid production causes synapse loss in hope of finding targets for future therapies
Rui Yi, Ph.D.
Genetic understanding of Down syndrome
Determine the effect of gene dosage imbalance on activity in trisomic embryonic stem cells

Meet the full Supergroup