Linda Crnic Institute
for Down Syndrome

The Global Down Syndrome Foundation provides fundraising, education, awareness and government advocacy for the Linda Crnic Institute for Down Syndrome.

Established in 2008, the Linda Crnic Institute for Down Syndrome is the first academic home for Down syndrome research in the United States. The mission of the Crnic Institute is to significantly improve the lives of people with Down syndrome by eradicating the medical and cognitive ill effects associated with the condition.

Learn more about the Linda Crnic Institute.
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  • Winter 2015 Down Syndrome World
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    Check Out the New Issue of "Down Syndrome World" Featuring John C. McGinley and His Son Max

  • Global Down Syndrome Foundation Educational Grants
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    Applications Now Available for 2015 Global Down Syndrome Foundation Educational Grants

  • Global Down Syndrome Foundation I Love You Dance Party
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    Global's Next I Love You Dance Party Is Friday, March 13th, in Denver. Sign up today!

  • Global Down Syndrome Foundation helps establish Trisomy 21 Research Society
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    Global Helps Establish Trisomy 21 Research Society; First Conference To Be in Paris in June

  • Sie Center's physical therapy expert Patricia Winders
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    Sie Center for Down Syndrome Physical Therapy Expert Patricia Winders Shares Tips, Hopes and Ideas

  • Alec Baldwin at the Be Beautiful Be Yourself Fashion Show
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    Be Beautiful Be Yourself Fashion Show Breaks Record by Raising $1.9 Million


Jamie Foxx and DeOndra Dixon
Jamie Foxx, on life with his little sister, DeOndra Dixon
Oscar and Grammy winner Jamie Foxx is a triple threat as an actor, musician and comedian, and he’s also a great big brother to self-advocate DeOndra Dixon. Foxx, who is a Global Down Syndrome Foundation Quincy Jones Exceptional Advocacy Award recipient, recently spoke with Down Syndrome World magazine about DeOndra and how she’s earned her own place in the spotlight.


Crnic Institute scholarship recipient Darian Williams
Crnic Institute launches undergraduate scholarship program
A new Undergraduate Scholarship Program being offered through the Linda Crnic Institute for Down Syndrome and the University of Colorado has the potential to expand existing Down syndrome research and get a new generation of undergraduates interested in studying Down syndrome.
Darian Williams, a 20-year-old molecular, cellular, and developmental biology major at CU, is the first recipient of the Crnic Institute’s undergraduate research scholarship.


Roberto Coin
Fashion designer Roberto Coin supports Global through long-time Global partner Hyde Park Jewelers. A recent dinner with the famous Italian jewelry designer and thought-leader raised nearly $20,000
Internationally renowned jewelry designer Roberto Coin lent his help to benefit the Global Down Syndrome Foundation on December 10, 2014, as long-time Global partner Hyde Park Jewelers hosted a benefit dinner. It’s the latest contribution in a long line of support from Hyde Park Jewelers.


Down Syndrome Association of Central Florida
Down Syndrome Association of Central Florida empowers self-advocates
The Down Syndrome Association of Central Florida (DSACF) was founded by a small group of families sitting around a kitchen table in 1991. Since then, DSACF’s mission of hope, encouragement, and acceptance has grown exponentially. Read more about this important group in an excerpt from Down Syndrome World magazine.


Salah Foundation
Salah Foundation Grant Provides for Programs for Adults with Down Syndrome
A generous matching grant from the Salah Foundation will provide $200,000 to underwrite Global’s important new initiative for adults with Down syndrome. The $200,000 in total matched funds allows Global to work with world-class researchers to create evidence-based educational programs for adults with Down syndrome in the areas of safety, health, nutrition, and communication & speech. Global intends to share the results of the research with the greater community in the hopes that programming that is proven will be replicated.


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Linda Crnic Institute for Down Syndrome
The Leader in scientific research benefiting people with Down syndrome

Meet the Crnic Institute Supergroup 2013 Grant Recipients

V. Balasubramaniam, M.D.
Sleep apnea and Down syndrome
Examine the effect of sleep apnea on vascular stem cells in people with Down syndrome
Christopher Link, Ph.D.
Genetic understanding of Down syndrome
Determine which genes have altered expression due to Trisomy 21
James DeGregori, Ph.D.
Leukemia and Down syndrome
Study increase in leukemia incidence and other problems with blood cell production, including reduced immunity
Karl Pfenninger, M.D.
Cognition and Down syndrome
Study causes of intellectual disability associated with Down syndrome, specifically the APP protein
Robin Dowell, Ph.D.
Genetic understanding of Down syndrome
Understand how Trisomy 21 affects the behavior of key proteins involved in regulating expression
Tamim H. Shaikh, Ph.D.
Autism and Down syndrome
Research genetic modifiers of autism spectrum disorders in patients with Down syndrome
Joaquin Espinosa, Ph.D.
Genetic understanding of Down syndrome
Identify genes whose function is essential in trisomic cells yet dispensable in cells with only two copies of chromosome 21
Richard Spritz, M.D.
Autoimmune disorders and Down syndrome
Analyze autoimmunity genetics in Down syndrome — thyroid disease, celiac disease, type 1 diabetes and rheumatoid arthritis
Fran Hickey, M.D.
Anesthesia and Down syndrome
Provide information to improve management of post-operative pain and sedation in children with Down syndrome
Ding Xue, Ph.D.
Alzheimer’s disease and Down syndrome
Study the roles of presenilin and ubiquilin in developing treatments for Alzheimer’s disease in patients with Down syndrome
Kevin Jones, Ph.D.
Gene regulation and Down syndrome
Test whether increasing the abundance of the BDNF protein can prevent Down syndrome pathology in a mouse model
Michael Yeager, Ph.D.
Autoimmune disorders and Down syndrome
Understand immune system disturbances in individuals with Down syndrome and drive development of newer therapies
Matthew Kennedy, Ph.D.
Alzheimer’s disease and Down syndrome
Investigate how increased beta-amyloid production causes synapse loss in hope of finding targets for future therapies
Rui Yi, Ph.D.
Genetic understanding of Down syndrome
Determine the effect of gene dosage imbalance on activity in trisomic embryonic stem cells

Meet the full Supergroup