Linda Crnic Institute Lectures: “Theory to Therapeutics in Mice and Men with Down Syndrome”

Roger Reeves, PhD

Roger Reeves, PhDProfessor, Johns Hopkins University School of Medicine
October 5, 2011

Click here to view a PowerPoint presentation called “Changing the Future for Down syndrome” summarizing Dr. Reeves’ Crnic Institute Lecture and other work related to Down syndrome

Roger Reeves, PhD, is a professor in the Department of Physiology at The Johns Hopkins University School of Medicine. His research goal is “to understand how gene dosage imbalance disrupts development in Down syndrome in order to develop and test potential therapies for Down syndrome features.” His research interests focus on mechanisms of gene action in Down syndrome and he has used mouse models to identify and test hypotheses concerning Down syndrome “critical regions” on human chromosome 21. Among recent findings are the identification of genes that play a key role in tumor resistance; determination that a deficit in cranial neural crest is the (initial) basis for the hypomorphic craniofacial skeleton that produces the characteristic appearance of individuals with Down syndrome; and the discovery of the basis for and a “treatment” of a fundamental neuronal deficit in the trisomic brain. He has a B.S. from Bowling Green State University, a Ph.D. from the University of Maryland, and a Postdoc from The Johns Hopkins University.